Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis

Abstract

The purpose of this study was to examine the allometric analyses of marbofloxacin, moxifloxacin, danofloxacin and difloxacin using pharmacokinetic data from the literature. The parameters of interest (half-life, clearance and volume of distribution) were correlated across species as a function of body weight using an allometric approach (Y = aWb). Results of the allometric analysis indicated similarity between clearance and volume of distribution as they relate to body weight for all drugs. The elimination half-life was independent of body mass for all fluoroquinolones except moxifloxacin. Results of the analysis suggest that allometric scaling can be used as a tool for predicting pharmacokinetic parameters for fluoroquinolones.

Allometric scaling of marbofloxacin pharmacokinetics: a retrospective analysis

“…Allometric estimates for marbofloxacin clearance and volume of distribution observed in the present study are in line with previously reported values (Cox 2007). However, estimates for marbofoxacin half-life across species (t 1/2β , b = 1.15) (Table 2) in this study is contrary to values presented in other study (Cox 2007).…”

“…However, estimates for marbofoxacin half-life across species (t 1/2β , b = 1.15) (Table 2) in this study is contrary to values presented in other study (Cox 2007). Theoretically expected allometric exponent values for clearance, half-life and volume of distribution of a drug that primarily cleared through kidney are 0.75, 0.25 (1 -0.75) and 0.67-1 respectively.…”

“…In addition the correlation between clearance and body weight was in line with previously reported interspecies difference in drug clearance (Boxenbaum 1980, Lin et al 1982. The scales for clearance, volume of distribution and half life of marbofloxacin observed in this study are in contrary to the scales for other floroquinolones (Cox 2004(Cox , 2007. Although scales for volume of distribution of marbofloxacin was frequently associated with body weight of different animal species (Haritova and Lashev 2009), the results obtained in this study (Table 2) suggest poor association between volume of distribution and body weight among species.…”

“…The allometric scaling based on the principle that major physiologic processes are related to body weight raised to allometric exponent (Riviere 1999). Hence, the association of physiologically dependent pharmacokinetics parameters such as clearance, volume of distribution and half-life of drugs with body weight has been previous studied (Cox 2004(Cox , 2007.…”

Interspecies Allometric Scaling of Antimalarial Drugs and Potential Application to Pediatric Dosing

“…Allometric scaling is a well-established technique for relating physiological or pharmacokinetic parameters to body weight (17)(18)(19)(20)(21)(22), and allometric relationships have been demonstrated for a wide range of drugs, including antimicrobial agents (23)(24)(25)(26)(27). The conventional applications of interspecies allometric scaling include prediction of human doses by extrapolation from preclinical animal studies and dose estimates for other mammalian species in veterinary medicine (18,23,26,28).…”