Alloimmune T cells in transplantation

DeWolf, Susan; Sykes, Megan

doi:10.1172/jci90595

Cited by 93 publications

(71 citation statements)

References 112 publications

(112 reference statements)

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“…Similarly, we identified minimal overlap between alloreactive TCRs and known public virus-reactive clones implicated in the response to pathogens, suggesting that alloreactive clones are not distinguished by a particular prior immunologic role. The ontogeny of alloreactive T cells has been somewhat enigmatic (29). Our current understanding reflects the inherent recognition of MHC/peptide by TCR structures and the flexibility in the configuration of TCR interactions with alternative ligands (30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Quantifying size and diversity of the human T cell alloresponse

DeWolf

Grinshpun²,

Savage

et al. 2018

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Quantifying size and diversity of the human T cell alloresponse

DeWolf

Grinshpun²,

Savage

et al. 2018

JCI Insight

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“…However, recent advances in identifying biomarkers of transplant tolerance [4, 6] and especially in measuring and tracking the recipient anti-donor alloreactive repertoire [6–8] are likely to facilitate such efforts in the future.…”

Section: Challenges In Translating Transplantation Tolerance To the Cmentioning

confidence: 99%

Mechanisms of Mixed Chimerism-Based Transplant Tolerance

Zuber

Sykes

2017

Trends in Immunology

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Immune responses to allografts represent a major barrier in organ transplantation. Immune tolerance to avoid chronic immunosuppression is a critical goal in the field, recently achieved in the clinic by combining bone marrow transplantation with kidney transplantation following non-myeloablative conditioning. At high levels of chimerism, such protocols can permit central deletional tolerance, yet with a significant risk of graft-versus-host disease (GVHD). In contrast, transient chimerism-based tolerance is devoid of GVHD risk and appears to initially depend on regulatory T cells followed by a gradual, presumably peripheral, clonal deletion of donor-reactive T cells. Here, we review recent mechanistic insights into tolerance and the development of more robust and safer protocols for tolerance induction that will be guided by innovative immune monitoring tools.

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“…Along the same lines, RNA-sequencing of subpopulations and analysis of specific of T cell receptor DNA sequences may identify patient specific auto-reactive clones, enabling individualized monitoring for disease recurrence. These approaches are being investigated in the setting of kidney transplantation, and offer the prospect for detection of transplant rejection before it is clinically apparent [25].…”

Section: Immune Surveillance and Prediction Of Relapsementioning

confidence: 99%

15th International Symposium on IgANephropathy – IIgANN 2018, Buenos Aires, September 27-29, 2018: Summaries

2018

Kidney Dis

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Alloimmune T cells in transplantation

Cited by 93 publications

References 112 publications

Quantifying size and diversity of the human T cell alloresponse

Quantifying size and diversity of the human T cell alloresponse

Mechanisms of Mixed Chimerism-Based Transplant Tolerance

15th International Symposium on IgANephropathy – IIgANN 2018, Buenos Aires, September 27-29, 2018: Summaries

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