Allograft transmission of hepatitis C during the window period: Weighing the new risks and costs in the era of donor shortage

Choe, Jennie; Merola, Jonathan; Kulkarni, Sanjay

doi:10.1111/ctr.13022

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Two recent cases of unexpected donor-derived HCV transmission in the United States highlight the profound shift in the clinical implications of HCV transmission in the current era. 123 In the first case, the donor suffered a cardiac arrest after an opiate overdose. Hepatitis C virus serology was negative; however, routine recipient follow-up at day 40 posttransplant identified proteinuria and recurrent focal segmental glomerulosclerosis.…”

Section: Viral Infections In the Deceased Donormentioning

confidence: 99%

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Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission

White

Rawlinson

Boan

et al. 2019

Transplantation Direct

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In 2016, the Transplantation Society of Australia and New Zealand, with the support of the Australian Government Organ and Tissue authority, commissioned a literature review on the topic of infectious disease transmission from deceased donors to recipients of solid organ transplants. The purpose of this review was to synthesize evidence on transmission risks, diagnostic test characteristics, and recipient management to inform best-practice clinical guidelines. The final review, presented as a special supplement in Transplantation Direct, collates case reports of transmission events and other peer-reviewed literature, and summarizes current (as of June 2017) international guidelines on donor screening and recipient management. Of particular interest at the time of writing was how to maximize utilization of donors at increased risk for transmission of human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, given the recent developments, including the availability of direct-acting antivirals for hepatitis C virus and improvements in donor screening technologies. The review also covers emerging risks associated with recent epidemics (eg, Zika virus) and the risk of transmission of nonendemic pathogens related to donor travel history or country of origin. Lastly, the implications for recipient consent of expanded utilization of donors at increased risk of blood-borne viral disease transmission are considered.

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Section: Viral Infections In the Deceased Donormentioning

confidence: 99%

“…The recipient completed 12 weeks of elbasvir/grazoprevir and HCV viral load remained undetectable upon completion of treatment. 123…”

Section: Viral Infections In the Deceased Donormentioning

confidence: 99%

Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission

White

Rawlinson

Boan

et al. 2019

Transplantation Direct

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show abstract

Hepatitis B and C virus infections transmitted through organ transplantation investigated by CDC, United States, 2014-2017

Bixler

Annambholta

Abara

et al. 2019

American Journal of Transplantation

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Allograft transmission of hepatitis C during the window period: Weighing the new risks and costs in the era of donor shortage

Cited by 2 publications

References 10 publications

Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission

Infectious Disease Transmission in Solid Organ Transplantation: Donor Evaluation, Recipient Risk, and Outcomes of Transmission

Hepatitis B and C virus infections transmitted through organ transplantation investigated by CDC, United States, 2014-2017

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