Allograft Tolerance after Total Lymphoid Irradiation (TLI)

Strober, Samuel; Slavin, Shimon; Gottlieb, Michael; Zan‐Bar, Israel; King, D P; Hoppe, Richard T.; Fuks, Zvi; Grumet, F. Carl; Kaplan, Henry S.

doi:10.1111/j.1600-065x.1979.tb00285.x

Cited by 135 publications

(60 citation statements)

References 21 publications

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“…2). At The long-lasting potent immunosuppressive effects of TLI have been well established in all animals studied so far (mice, rats, and dogs) including man (13)(14)(15)(17)(18)(19). TLI results in thymus-derived (T) lymphocytopenia as well as impairment of T cell functions including elimination of the in vitro responsiveness to phytohemagglutinin and the in vitro reactivity to alloantigens in a one-way mixed lymphocyte reaction.…”

Section: Resultsmentioning

confidence: 99%

“…TLI enabled engraftment of allogeneic bone marrow grafts without overt graft-versus-host disease and establishment of specific and permanent transplantation tolerance across major histocompatibility barriers in mice (C57BL/Ka, H -2b BALB/c, H-2 ), rats (ACI, AgB4 -Lewis, AgB'), and mongrel dogs (13,14,(17)(18)(19)(20). The effects of TLI result in immediate profound lymphocyte depletion with subsequent generation of nonspecific as well as specific suppressor T cells (21,22).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.

Slavin¹

1979

Proc. Natl. Acad. Sci. U.S.A.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.

Slavin¹

1979

Proc. Natl. Acad. Sci. U.S.A.

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“…The total dose of radiation administered to the lymphoid tissues above and below the diaphragm in patients with Hodgkin's disease is approximately 4,400 cGy in doses of 100 to 250 cGy each (14). We modified this radiation protocol for studies of organ transplantation tolerance in laboratory animals including inbred rodents and large outbred animals (15).…”

Section: Transplantation Tolerance and Mixed Chimerism Using Pretransmentioning

confidence: 99%

Approaches to transplantation tolerance in humans

Strober¹,

Lowsky

Shizuru

et al. 2004

Transplantation

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Although transplantation tolerance to organ allografts has been achieved using a wide variety of immunologic interventions in laboratory animals, few tolerance induction protocols with complete immunosuppressive drug withdrawal have been tested in humans. Preclinical and clinical studies of the use of total lymphoid irradiation for the induction of chimeric and nonchimeric tolerance are summarized here.

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“…Pro-[5, [8][9][10]111. In addition in some models TLI together found immunosuppressive properties of TLI observed in with chemical immunosuppression has resulted in signifmice and rats given TLI have stimulated workers to focus icant organ allograft survival without the necessity of their studies on the use of selective lymphoid depletion corticosteroids or concomitant marrow transplantation so as to suppress organ allograft rejection [9]. The appli-[ 121. cation of fractionated high-dose TLI takes advantage of…”

Section: Loid and Megakaryocytic Series (H And E X 200)mentioning

confidence: 99%

The effect of ionizing radiation on the primate pancreas: An endocrine and morphologic study

Toit

Heydenrych

Smit

et al. 1987

Journal of Surgical Oncology

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In this study we evaluated the endocrine, biochemical, and haematological derangements as well as pancreatic and histological changes of the bonemarrow in the primate following external fractionated subtotal marrow irradiation without bonemarrow reconstitution. The irradiation was administered in preparation for pancreatic transplantation. Two groups of animals (ten in each group) received 800 rad (8 Gy) and 1,000 rad (10 Gy) respectively over 4 to 5 weeks. A maximum of 200 rads (2 Gy) were administered weekly as photons from a 6 MV linear accelerator. During irradiation the animals remained normoglycaemic in the presence of transiently elevated liver enzymes and serum amylase values, which returned to normal on completion of the irradiation. Insulin release was significantly reduced in both groups during irradiation and was associated with minimally decreased K-values in the presence of mild glucose intolerance. Pancreatic light morphologic changes included structural changes of both exocrine and endocrine elements and included necrosis of the islet cells and acinar tissue. Islet histology demonstrated striking cytocavitary network changes of alpha and beta cells, including degranulation, vacuolization, mitochondrial destruction, and an increase in lysosomes. A hypoplastic bonemarrow ranging from moderate to severe was observed in all irradiated recipients. Near total fractionated body irradiation in the primate is therefore associated with elevated liver enzymes, pancytopenia, transient hyperamylasaemia, hypoinsulinaemia, a varying degree of pancreatitis, and bonemarrow hypoplasia.

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Allograft Tolerance after Total Lymphoid Irradiation (TLI)

Cited by 135 publications

References 21 publications

Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.

Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.

Approaches to transplantation tolerance in humans

The effect of ionizing radiation on the primate pancreas: An endocrine and morphologic study

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