Allograft Is Superior to Topical Antimicrobial Therapy in the Treatment of Partial-Thickness Scald Burns in Children

Management of Blisters in the Partial-Thickness Burn: An Integrative Research Review

“…The results favored biological and biosynthetic dressings for increased rates of wound healing, decreased scarring, reduction in the number of required dressing changes, and cost efficiency without significant differences in infection rates. [15][16][17][18][19][20][21] As technological scientific capabilities progressed in the laboratory setting, burn research also turned its interest to blister fluid and its inherent wound healing effects. Experiments in this area began in the late 1970s and have used both animal and human models, in vivo and in vitro.…”

“…Both clinical reviews and experimental research have described the decreased need for multiple dressings changes associated with biosynthetic and biologic temporary skin substitutes applied over the wound bed of débrided partial-thickness burns. [15][16][17][18][19][20][21]86 Although the initial application may require more time and clinical skill than is necessary for the application of topical antibiotic creams and ointments, the associated benefit for both the patient and the provider is that of minimal wound care for the duration of healing. Synthetic dressings such as hydrocolloids and occlusive preparations offer a similar decrease in the requirement for frequent dressing changes.…”

“…[17][18][19][20] The superior physiologic healing environment provided by these temporary skin substitutes supports the débridment of blisters for their use. Allograft availability limits use of this product, as does concern for disease transmission, although this has not been demonstrated in any clinical trial.…”

“…The research suggests that the use of SSD in partial-thickness burns with blisters is not beneficial to healing in comparison with other available products and the ease of its use for the practitioner should not supersede the healing needs of the patient. [15][16][17][18][19][20][21] Several studies have compared topical enzymatic débriding agents to SSD in partial-thickness burns. Hansbrough 71 and Hansbrough et al 72 demonstrated faster healing rates with collagenase ointment while Soroff and Sasvary 73 had similar results with collagenase ointment and polymyxin B sulfate/bacitracin spray combination in comparison with SSD.…”

Aquacel Ag® in the Management of Partial-Thickness Burns: Results of a Clinical Trial

“…1 Deeper areas that will not heal in a relatively short time, or heal at all without surgical intervention, will require excision and grafting which is often performed within two to three days after pre-sentation. Whereas the treatment protocol for first and third degree (full-thickness) burns is clearly defined, the algorithm for mixed partial-thickness burn wounds presents a dilemma.…”