Allograft Donor Characteristics Significantly Influence Graft Rupture After Anterior Cruciate Ligament Reconstruction in a Young Active Population: Letter to the Editor

Maletis, Gregory B.; Prentice, Heather A.; Funahashi, Tadashi T.; Tejwani, Samir G.

doi:10.1177/0363546520982991

Cited by 2 publications

(2 citation statements)

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“…Considering the patellar tendon and Achilles tendon, which are among the most used [6,21] and investigated, it was clear that the studies available are not sufficient to indicate 50 or 60 years of donor age as a reasonable cut-off. The study by Shelton et al [26] was the only one to clearly identify an age effect on patellar tendon allograft in terms of reduced load to failure and tensile strength after 50 years, but they also stated no differences were identified for elasticity parameters, stiffness and viscoelastic properties.…”

Section: Discussionmentioning

confidence: 99%

“…In the setting of primary ACL reconstruction, autografts are the grafts of choice. At the same time, allografts are widely used in revision ACL reconstruction and multiple ligament knee reconstructions as first-line grafts [4,7,21,23]. This preference for allografts is rooted in various advantages they offer, including reduced donor site morbidity, decreased surgical time, smaller skin incisions and the avoidance of injury to the extensor or flexor apparatus [16,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Donor age has no relevant role in biomechanical properties of allografts used in anterior cruciate ligament (ACL) reconstruction: A systematic review

Grassi,

Agostinone,

Di Paolo

et al. 2024

Knee surg. sports traumatol. arthrosc.

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PurposeSurgeons generally consider the donor age as a factor that negatively influences the quality of allograft used in anterior cruciate ligament (ACL) reconstruction, however, the available evidence does not clearly support this statement. The purpose of the study was to investigate if donor age influences the biomechanical properties of allografts used in ACL reconstruction.MethodsA comprehensive literature search was conducted for all relevant articles using MEDLINE (PubMed), Scopus, and Cochrane Collaboration Library, according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis. Studies including the analysis of the correlation between biomechanical properties of the allografts and donor age were selected. The role of donor age was labelled as ‘none’ if absent, ‘higher’ or ‘lower’ if the properties were higher or lower in older specimens with respect to younger. The correlation was defined as ‘weak’ or ‘strong’ according to each study definition.ResultsNo conflicting role of donor age was reported for modulus of elasticity, load to failure, strain, stiffness and displacement. The only parameters where the significant results were consistent were the tensile strength and the stress (low or moderate correlations). When considering the tested samples with a donor's age <65 years, a significant role of age was reported in only four out of 13 groups of graft tested (patellar tendon, fascia lata, anterior tibialis tendon and posterior tibialis tendon).ConclusionThe current literature did not allow to state that the donor age negatively influences the biomechanical properties of allografts, making it impossible to identify a clear age cut‐off value to exclude them from ACL reconstruction procedures.Level of EvidenceLevel IV, systematic review.

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Section: Discussionmentioning

confidence: 99%