Allograft Bone

Boyce, T. M.; Edwards, Jean T.; Scarborough, Nelson

doi:10.1016/s0030-5898(05)70110-3

Cited by 312 publications

(59 citation statements)

References 71 publications

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“…More than 2.2 million bone grafts are used world-wide every year (15). Autogenous bone graft is noteworthy as being the most frequently selected graft for these procedures (5). Autogenous bone contains bone minerals, collagen, growth factors and osteoprogenitor cells required for osteoconduction and osteoinduction.…”

Section: Resultsmentioning

confidence: 99%

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

Atılgan¹,

Yaman²,

Yilmaz³

et al. 2007

Biotechnology & Biotechnological Equipment

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Section: Resultsmentioning

confidence: 99%

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

Atılgan¹,

Yaman²,

Yilmaz³

et al. 2007

Biotechnology & Biotechnological Equipment

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“…Because of these measures, immunological rejection, depending on the method applied for graft preservation and the potential risk of viral, bacterial or prion transmission associated with allograft transplantation, has been well controlled at a clinically acceptable level. During the 30-year history of the use of freeze-dried allograft bone in reconstructive surgery, there have been very few reports of disease transmission [141,227,230]. Tissue banks process bone allografts using various methods, with several based on proprietary techniques; however, most are based on similar underlying concepts that address cleansing, decontamination, antimicrobial treatment, dehydration, graft sizing and terminal sterilization [230].…”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

“…Additionally, certain processing techniques have been associated with detrimental impacts on the biological and mechanical properties of cortical bone allografts. For example, freeze drying may cause microcracks in the bone, and gamma irradiation increases bone brittleness [227]. …”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

“…Alternatively, the treatment of mineralized bone allografts with a 1:1 formic acid–citric acid mixture or with hydrochloric acid (0.5–0.6 M) can remove inorganic elements, yielding a natural polymer product that is generally referred to as demineralized bone matrix (DBM) [50,242]. As an acellular organic matrix, DBM mimics the microstructure of native bone but is less immunogenic and possesses good osteoinductive and osteoconductive performance [227,242]. DBM contains the major protein components of bone, such as adhesion ligands and osteoinductive growth factors that may contribute to new bone formation [243].…”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

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Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

926

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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“…Although allografts undergo multiple treatments prior to use, risk of disease transmission is still a possibility. It has been estimated that the risk of human immunodeficiency virus (HIV) transmission is 1 in 1.6 million with use of allografts [193]. There have been some reports of cross-infection and incidences of disease transmission of bovine spongiform encephalopathy [194,195,196].…”

Section: Natural Transplants and Synthetic Bone Replacement Graft mentioning

confidence: 99%

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

Sima²,

2015

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Alveolar bone augmentation in vertical dimension remains the holy grail of periodontal tissue engineering. Successful dental implant placement for restoration of edentulous sites depends on the quality and quantity of alveolar bone available in all spatial dimensions. There are several surgical techniques used alone or in combination with natural or synthetic graft materials to achieve vertical alveolar bone augmentation. While continuously improving surgical techniques combined with the use of auto- or allografts provide the most predictable clinical outcomes, their success often depends on the status of recipient tissues. The morbidity associated with donor sites for auto-grafts makes these techniques less appealing to both patients and clinicians. New developments in material sciences offer a range of synthetic replacements for natural grafts to address the shortcoming of a second surgical site and relatively high resorption rates. This narrative review focuses on existing techniques, natural tissues and synthetic biomaterials commonly used to achieve vertical bone height gain in order to successfully restore edentulous ridges with implant-supported prostheses.

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Allograft Bone

Cited by 312 publications

References 71 publications

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

Advancing biomaterials of human origin for tissue engineering

Bone Replacement Materials and Techniques Used for Achieving Vertical Alveolar Bone Augmentation

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