Allogeneic transplant graft source – conditioning – GVHD prophylaxis: don’t mix and match!

Gomez-Arteaga, Alexandra; Besien, Koen van

doi:10.1080/10428194.2021.2005048

Cited by 1 publication

(5 citation statements)

References 14 publications

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“…Other factors are the history of infections of the donor as well as the post-transplant infections of the recipient and the age of both, donor and recipient. They all influence the diversity of the recipient TCR repertoire [8][9][10][11]. Infections post transplant influence the TCR diversity due to an increase in antigen-specific TCRs [30,31].…”

Section: G V H D P R O P H Y La X Ismentioning

confidence: 99%

“…Infections post transplant influence the TCR diversity due to an increase in antigen-specific TCRs [30,31]. GvHD prophylaxis requires immunosupressive therapies that influence the TCR repertoire, by depleting T cells [7,8]. Conditioning regiment involving chemotherapy and radiotherapy leads to the damage of the thymus.…”

Section: G V H D P R O P H Y La X Ismentioning

confidence: 99%

“…This delays thymic recovery influences the dynamics of immune reconstitution and thus the time-dependent recovery of the TCR repertoire. The activation of APCs in recipient tissues is one of the important factors responsible for GvHD [8,10].…”

Section: G V H D P R O P H Y La X Ismentioning

confidence: 99%

“…1 can affect the TCR repertoire and thus the TCR diversity post allo-SCT and in GvHD. The donor-recipient compatibility, age of the patient, immunosuppressive therapies as part of GvHD prophylaxis, previous damage to thymus by conditioning regimen are few of the several factors contributing to the dynamics of T cell regeneration and repertoire post allo-SCT [7][8][9][10][11][38][39][40]. Additionally, conflicting results of TCR diversity could result from differences in the allowed HLA mismatches, which may not have been considered during analysis.…”

Section: Tcr Diversity In Peripheral Repertoires Of Patients Affected...mentioning

confidence: 99%

“…(Fig. 1) [2,3,[7][8][9][10][11]. Here, we review the AIRR sequencing studies on T cells in GvHD post HSCT.…”

Section: Introductionmentioning

confidence: 99%

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Potential of TCR sequencing in graft-versus-host disease

Goel

Eugster

Schetelig

et al. 2022

Bone Marrow Transplant

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Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic haematopoietic stem cell transplantation (allo-HSCT). GvHD can occur in almost every tissue, with the skin, liver, and intestines being the mainly affected organs. T cells are implicated in initiating GvHD. T cells identify a broad range of antigens and mediate the immune response through receptors on their surfaces (T cell receptors, TCRs). The composition of TCRs within a T cell population defines the TCR repertoire of an individual, and this repertoire represents exposure to self and non-self proteins. Monitoring the changes in the TCR repertoire using TCR sequencing can provide an indication of the dynamics of a T cell population. Monitoring the frequency and specificities of specific TCR clonotypes longitudinally in different conditions and specimens (peripheral blood, GvHD-affected tissue samples) can provide insights into factors modulating immune reactions following allogeneic transplantation and will help to understand the underlying mechanisms mediating GvHD. This review provides insights into current studies of the TCR repertoire in GvHD and potential future clinical implications of TCR sequencing.

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