Allogeneic transplant compared to pediatric-inspired therapy for Philadelphia chromosome-negative adolescent and adult ALL in first complete remission

Outcomes of allogeneic or autologous stem cell transplantation followed by maintenance chemotherapy in adult patient with B‐ALL in CR1 with no detectable minimal residual disease

“…and chimeric antigen receptor T cells characterized by a high response rate and acceptable tolerance, have been witnessed 3–5 . For adolescents and young adults, paediatric‐inspired protocols may achieve comparable or even potentially better results without upfront allo‐HSCT 6 . In Philadelphia chromosome‐positive ALL (Ph + ALL), second‐ and third‐generation tyrosine kinase inhibitors (TKIs) have been shown to overcome multiple ABL mutations due to their stronger and faster activity against BCR‐ABL, allowing more patients to achieve minimal residue disease (MRD) negativity, reduce treatment resistance and relapse 7 .…”

“…[3][4][5] For adolescents and young adults, paediatric-inspired protocols may achieve comparable or even potentially better results without upfront allo-HSCT. 6 In Philadelphia chromosome-positive…”