Allogeneic T cell responses are regulated by a specific miRNA-mRNA network

Sun, Yaping; Tawara, Isao; Zhao, Meng; Qin, Zhaohui S.; Toubai, Tomomi; Mathewson, Nathan D.; Tamaki, Hiroya; Nieves, Evelyn; Chinnaiyan, Arul M.; Reddy, Pavan

doi:10.1172/jci70013

Cited by 38 publications

(35 citation statements)

References 59 publications

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“…The discrepancy in T-cell miRNA signatures between human AA and the murine bone marrow failure models may be due to the difference of species and/or mouse bone marrow failure models based on minor-histocompatibility antigen-mismatched graft-versus-host disease reactions, given the fact that the dysregulations of miRNA in our model overlapped with those in previous reports. 23,24 We speculate that the mouse models based on MHC mismatching at least in part share miRNA signatures associated with allo-reactivity.…”

Section: Discussionmentioning

confidence: 98%

Identification of novel microRNA signatures linked to acquired aplastic anemia

et al. 2015

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Section: Discussionmentioning

confidence: 98%

Identification of novel microRNA signatures linked to acquired aplastic anemia

et al. 2015

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“…But its role in adaptive immunity, specifically for naive T cell development and function, remains unknown. Recently, we showed that miR-142 is among the most dysregulated miRs following allogeneic stimulation of naive T cells (15). Based on these observations, we proposed a model suggesting that miR-142 modulates T cells and critically affects acute GVHD severity and mortality.…”

Section: Introductionmentioning

confidence: 95%

“…We also chose this model because previous study demonstrated significant alterations in the expression of miR-142 in T cells following allostimulation (15). We utilized a well-characterized T cell-dependent MHC disparate allogeneic bone marrow transplant (BMT) model (B6 into BALB/c) and performed BMT with 1 × 10 6 cells from WT-Ly5.2/CD45.1, or Mir142 -/--Ly5.1/CD45.2 along with WT T cell-depleted (TCD) BM (5 × 10 6 ) into BALB/c.…”

Section: Mir-142 Ko T Cells Show Altered T Cell Proliferative Responsmentioning

confidence: 99%

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Mature T cell responses are controlled by microRNA-142

Sun¹,

Oravecz-Wilson²,

Mathewson³

et al. 2015

J. Clin. Invest.

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“…23 miRNAs have recently gained attention as pertinent candidates in the field of organ transplantation due to their ability to control innumerable genes that are critical components of immune responses. [24][25][26] Previous studies have attempted to identify the miRNAs expressed in the graft after cardiac transplant in rodent models. 27,28 The murine allograft model showed that 42 miRNAs were up-regulated and 32 miRNAs were downregulated in allogeneic cardiac grafts as compared with syngeneic cardiac grafts 7 days after grafting.…”

Section: Discussionmentioning

confidence: 99%

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Fujino¹,

Zhu

Cai³

et al. 2016

Exp Clin Transplant

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Objectives: Induction of immunologic tolerance is the ultimate goal of organ transplant. To investigate the involvement of microRNA in tolerance induction after organ transplant, murine cardiac allografts were performed and the expression of microRNA in the grafts was analyzed. Materials and Methods: Cardiac allografts were performed using C57BL/10 (H2-Kb) to CBA/N (H2-Kk) fully mismatched combination with or without eicosapentaenoic acid for tolerance induction. Ten microRNA, mir-146a, 15b, 223, 23a, 27a, 34a, 451, 101a, 101b, 148a, discovered in hepatic grafts were examined by quantitative reverse transcription polymerase chain reaction using RNA from the cardiac allografts. Results: The administration of eicosapentaenoic acid markedly prolonged the cardiac allograft survival (median survival time > 100 days) and decreased the pathological score. Quantitative reverse transcription polymerase chain reaction revealed that mir-223 was up-regulated in accordance with pathological deterioration as compared with the expression observed in the syngeneic grafts. In contrast, the other microRNA was down-regulated. Pearson product moment correlation analysis demonstrated that the expression patterns of mir-223 and mir-146a had high or moderate positive associations between the cardiac and haptic allografts in mice. Conclusions:The change in the microRNA expression in the allografts suggests that microRNA plays a role in the induction and/or maintenance of tolerance after allograft transplant. Our findings suggest that mir-223 may be associated with rejection while mir-146a, -15b, -23a, -27a, -34a, -451, -101a, -101b, -148a may be involved in tolerance. A superior grasp of the mec hanism for rejection and tolerance observed in the murine heart allotransplant model may provide a better curative treatment strategy to mitigate allograft rejection.

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Allogeneic T cell responses are regulated by a specific miRNA-mRNA network

Cited by 38 publications

References 59 publications

Identification of novel microRNA signatures linked to acquired aplastic anemia

Identification of novel microRNA signatures linked to acquired aplastic anemia

Mature T cell responses are controlled by microRNA-142

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