2013
DOI: 10.1038/bjc.2013.630
|View full text |Cite
|
Sign up to set email alerts
|

Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment

Abstract: Background:Allogeneic haematopoietic stem cell transplantation (allo-SCT) may provide donor cytotoxic T cell-/NK cell-mediated disease control in patients with rhabdomyosarcoma (RMS). However, little is known about the prevalence of graft-vs-RMS effects and only a few case experiences have been reported.Methods:We evaluated allo-SCT outcomes of 30 European Group for Blood and Marrow Transplantation (EBMT)-registered patients with advanced RMS regarding toxicity, progression-free survival (PFS) and overall surv… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

4
33
1
1

Year Published

2015
2015
2022
2022

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 23 publications
(39 citation statements)
references
References 49 publications
(76 reference statements)
4
33
1
1
Order By: Relevance
“…The major cause of death still is relapse followed by transplant-related toxicity, post transplant infections and GvHD. 10,11 In mismatched haploidentical transplantation, natural killer (NK) cells have been shown to exert significant GvL effects in the presence of KIR ligand incompatibility in GvH direction. 12,13 In pediatric solid tumors, this has also been observed in a limited number of patients.…”
Section: Introductionmentioning
confidence: 99%
“…The major cause of death still is relapse followed by transplant-related toxicity, post transplant infections and GvHD. 10,11 In mismatched haploidentical transplantation, natural killer (NK) cells have been shown to exert significant GvL effects in the presence of KIR ligand incompatibility in GvH direction. 12,13 In pediatric solid tumors, this has also been observed in a limited number of patients.…”
Section: Introductionmentioning
confidence: 99%
“…Some reports indicate that the lessons learned from immunotherapy of melanoma patients could be potentially translated to other solid tumor entities [9]. However, in the pediatric sarcoma setting, tumor immunogenicity remains yet to be determined [4, 6, 13, 14, 2225]. The possibility to target tumor cell antigens essential for survival and proliferation, including transcription factors such as CHM1 renders the use of peptide specific T cells is very attractive.…”
Section: Discussionmentioning
confidence: 99%
“…In recent analyses on the role of allogeneic stem cell transplantation in the treatment of AES patients we demonstrated high treatment toxicity due to graft versus host disease (GVHD) but absence of a graft-versus-ES effect in HLA-matched settings [12, 13]. In a further analysis we demonstrated tumor control in several patients with rhabdomyosarcoma who received unspecific donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation [14]. Taken together, these findings indicate that allogeneic stem cell transplantation may not be sufficient to control cancer by itself, but may serve as platform or model for immunotherapeutic approaches.…”
Section: Introductionmentioning
confidence: 99%
“…Some reports indicate that the lessons learned from immunotherapy of melanoma patients could be potentially translated to other solid tumor entities [9]. However, in the pediatric sarcoma setting, tumor immunogenicity remains yet to be determined [4,6,13,14,[22][23][24][25]. The possibility to target tumor cell antigens essential for survival and proliferation, including transcription factors such as CHM1 renders the use of peptide specific T cells is very attractive.…”
Section: Discussionmentioning
confidence: 99%
“…In recent analyses on the role of allogeneic stem cell transplantation in the treatment of AES patients we demonstrated high treatment toxicity due to graft versus host disease (GVHD) but absence of a graftversus-ES effect in HLA-matched settings [12,13]. In a further analysis we demonstrated tumor control in several patients with rhabdomyosarcoma who received unspecific donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation [14]. Taken together, these findings indicate that allogeneic stem cell transplantation may not be sufficient to control cancer by itself, but may serve as platform or model for immunotherapeutic approaches.…”
Section: Introductionmentioning
confidence: 99%