“…A rapidly increasing number of studies use PL, rather than FBS, as nutritional supplement in cell culture media for human cell culture (Astori et al, ; Burnouf, Strunk, Koh, & Schallmoser, ; Ruggiu, Ulivi, Sanguineti, Cancedda, & Descalzi, ). Except for the beneficial effects on the mineralization of ADMSCs, platelet derivatives were also shown to exert an anti‐inflammatory effect on monocytes/macrophages (Linke et al, ; Papait, Cancedda, Mastrogiacomo, & Poggi, ; Renn, Kao, Wang, & Burnouf, ). Furthermore, PL contains a high concentration of TGF‐β as reported previously, with fluctuations from 900 to 15,000 pg/ml (Fekete et al, ; Renn et al, ; Salvade et al, ).…”