Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation for nagase's analbuminemic rats

Kokudo, Norihiro; Horimoto, Hitoshi; Ishida, Kazumi; Takahashi, Shigeki; Nozawa, Masumi

doi:10.1016/0963-6897(96)00033-4

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…[58][59][60] The xenogeneic hepatocytes from mice could also exhibit hepatization function and morphological structure after intrasplenic grafting under tacrolimus (FK506) immunosuppression. 61 However, for larger animals such as dogs, monkeys, and humans, there were no definite findings regarding the functional support of damaged livers by transplanted hepatocytes F I G U R E 2 Scheme of the anatomical structure and tissue microenvironment of the spleen. ECM, extracellular matrix.…”

Section: Spleen: a Suitable Organ For Transformation And Associated C...mentioning

confidence: 99%

“…The allogenic primary hepatocytes injected into the spleen of congenic Nagase analbuminemic rats could perform glycogen metabolism, albumin synthesis, bile secretion, and other physiological functions and survive over the long term 58–60 . The xenogeneic hepatocytes from mice could also exhibit hepatization function and morphological structure after intrasplenic grafting under tacrolimus (FK506) immunosuppression 61 . However, for larger animals such as dogs, monkeys, and humans, there were no definite findings regarding the functional support of damaged livers by transplanted hepatocytes in the spleen 62 .…”

Section: Spleen: a Suitable Organ For Transformation And Associated C...mentioning

confidence: 99%

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Transforming one organ into another to overcome challenges in tissue engineering

Wang

Tian

Wang

et al. 2022

Portal Hypertension & Cirrhosis

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Tissue engineering (TE) is promising for the regeneration of failed organs. However, immune rejection, shortage of seed cells, and unintegrated blood vessels restrict the development and clinical application of TE. The last factor is the most challenging and intractable. Harnessing the mature blood vessel network in existing dispensable organs could be a powerful approach to effectively overcome the obstacles. After being remodeled to harbor an immunosuppressive and proregenerative niche, these potential target organs can be transformed into other organs with specific physiological functions, compensating the latter's failed native functions. Organ transformation, such as a hepatized spleen, represents an effective and encouraging TE strategy. In this review, we discuss the current development and obstacles of TE and its feasibility and superiority in organ transformation.

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Section: Spleen: a Suitable Organ For Transformation And Associated C...mentioning

confidence: 99%

Section: Spleen: a Suitable Organ For Transformation And Associated C...mentioning

confidence: 99%

Transforming one organ into another to overcome challenges in tissue engineering

Wang

Tian

Wang

et al. 2022

Portal Hypertension & Cirrhosis

View full text Add to dashboard Cite

show abstract

“…It is believed that it can bridge patients to whole organ transplantation 1 . In addition to the allogenic hepatocytes 2 , xenogenic hepatocytes 3 and hepatocytes derived from stem cells 4 are also being investigated in animal models. In this context, the homing and engraftment potential of the transplanted cells in the recipient is an important criterion for cell based therapy in acute hepatic failure (AHF).…”

Section: Introductionmentioning

confidence: 99%

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Das

Bhattacharjee

Preeti

et al. 2018

JoVE

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Partial hepatectomy is a versatile and reproducible method to study liver regeneration and the effect of cell based therapeutics in various pathological conditions. Partial hepatectomy also facilitates the increased engraftment and proliferation of transplanted cells by accelerating neovascularization and cell migration towards the liver. Here, we describe a simple protocol for performing 30% hepatectomy and transplantation of cells in the spleen of a non-obese diabetic/severe combined immunodeficient NOD.SCID (NOD.CB17-Prkdc/J) mouse. In this procedure, two small incisions are made. The first incision is to expose and resect the left lobe of the liver, and another small incision is made to expose the spleen for the intrasplenic transplantation of cells. This procedure does not require any specialized surgical skills, and it can be completed in 5-7 minutes with less stress and pain, faster recovery, and better survival. We have demonstrated the transplantation of hepatocytes isolated from a green fluorescent protein (GFP) expressing mouse (Transgenic C57BL/6-Tg (UBC-GFP) 30Scha/J), as well as hepatocyte like cells of human origin (NeoHep) in partially hepatectomized NOD.SCID mice.

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Human hepatocyte transplantation: biology and therapy

Fisher

Strom

2000

The Hepatocyte Review

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Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation for nagase's analbuminemic rats

Cited by 8 publications

References 5 publications

Transforming one organ into another to overcome challenges in tissue engineering

Transforming one organ into another to overcome challenges in tissue engineering

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Human hepatocyte transplantation: biology and therapy

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