“…Treatment options include withdrawal of immune suppressants (IS), chemotherapy, local radiation therapy, lymphocyte infusions (DLIs) from the original donor, and second allo-SCT, but there are limited data describing the outcome of each treatment. 12,17,19,21,22 It has been shown that the graft-versus-ATL (GVATL) effect plays an important role in the prevention of relapse 13,19,21,23,24 and therapy that could induce the GVATL reaction may improve postrelapse outcome. DLI, a therapy that would induce a GVL reaction, has gained a prominent role in the management of leukemia patients who relapse after allo-SCT.…”