Allogeneic Bone Marrow Transplantation in Multiple Myeloma

Abstract

A 28-year-old woman with Bence-Jones multiple myeloma (MM) presented with several osteolytic lesions and a massive bone marrow infiltration with mature plasmocytes. After 6 cycles of chemotherapy with melphalan and prednisone, the patient, in apparent clinical remission, underwent allogeneic bone marrow transplantation (BMT) from her brother. The patient has been followed up for 23 months, showing complete remission by clinical and laboratory criteria. Other cases of MM treated with BMT and reported in the literature are reviewed and discussed.

Bone Marrow Transplantation

“…AlloBMT is up to now the only therapeutic measure capable of achieving long-term disease-free survival. There have been many single-centre studies, and both the modified BU-CY regimen [165] and highdose multi-agent chemo-radiotherapy [406][407][408][409][410] have been employed. The most important clinical material has been assembled by the EBMT [409,410].…”