Allogeneic bone marrow transplantation from a donor with severe active rheumatoid arthritis not resulting in adoptive transfer of disease to recipient

Snowden, John A.; Atkinson, K; Kearney, Philip C.; Brooks, P. M.; Biggs, J. C.

doi:10.1038/sj.bmt.1700835

Cited by 35 publications

(20 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, one could speculate that recipient (host) factors, including inherent defects in central or peripheral tolerance, are important. This is supported by recent reports that BMT from donors with severe systemic autoimmune disease does not necessarily produce adoptive autoimmunity in HLA-matched siblings (20).…”

Section: Discussionsupporting

confidence: 74%

Long‐term outcome of autoimmune disease following allogeneic bone marrow transplantation

Snowden

Kearney

et al. 1998

Arthritis & Rheumatism

116

View full text Add to dashboard Cite

Long-term followup of autoimmune disease after allogeneic transplantation confirmed cure of the autoimmune disease in some, but eventual relapse in others. The occurrence of relapse despite complete donor hemopoietic reconstitution is evidence for the development of de novo, as opposed to persistent, disease, and is possibly related to intrinsic susceptibility of the transplanted stem cells or to host factors. There may be a relationship between remission of autoimmune disease and graft-versus-host reaction. These findings have relevance for the evolving application of stem cell transplantation as a therapy for autoimmune diseases.

show abstract

Section: Discussionsupporting

confidence: 74%

Long‐term outcome of autoimmune disease following allogeneic bone marrow transplantation

Snowden

Kearney

et al. 1998

Arthritis & Rheumatism

116

View full text Add to dashboard Cite

show abstract

“…It is of interest that autoimmunity was not transferred to recipients of unmanipulated marrow from HLAidentical donors with rheumatoid arthritis and systemic lupus erythematosus, respectively. 10 It has been proposed that fundamental differences in pathophysiology may account for the apparent transfer by BMT of organ-specific diseases and not (to date) of systemic rheumatic AD. 10 The existence of therapeutically controlled AD in a SC donor does not contraindicate BMT for the donor-recipient pair, but requires attentive immunological monitoring.…”

Section: Discussionmentioning

confidence: 99%

Adoptive autoimmune hyperthyroidism following allogeneic stem cell transplantation from an HLA-identical sibling with Graves’ disease

Berisso

Lint

Bacigalupo

et al. 1999

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Autoimmune diseases which follow allogeneic BMT from a donor who is a patient or a carrier of an autoimmune condition are considered to be a paradigm of adoptive autoimmunity. Seven cases of autoimmune thyroiditis associated with clinical hyperthyroidism have been published to date. In the case reported here a 35-year-old female patient with AML of the M2 subtype received unmanipulated PBSC from her HLA-identical sister who had therapeutically controlled Graves' disease. Antithyroid antibodies, including thyrotropin receptor (TSHR) antibodies, appeared 1 year after transplant. Clinical hyperthyroidism requiring thyrostatic medication appeared after 2 years. The biological and clinical implications of adoptive, post-transplant autoimmunity are briefly discussed.

show abstract

“…8 However, systemic autoimmune disease such as RA or systemic lupus erythematosus is rarely transferred, possibly due to the complexity of the cellular immune disorder of RA, with multicellular dysfunction of lymphocytes, monocytes and antigen-presenting cells. Furthermore, a case report 9 demonstrating that allogeneic bone marrow transplantation from a donor with severe active RA did not result in adoptive transfer to the recipient suggests that additional genetic predisposing factors may be required for the development of RA, as observed in our case. Koch et al 10 described three patients who presented with rheumatic symptoms following autologous stem cell transplantation.…”

Section: Discussionmentioning

confidence: 80%

Development of rheumatoid arthritis following autologous peripheral blood stem cell transplantation

Imamura

Inoue

Katô

et al. 2002

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:A 51-year-old man with non-Hodgkin's lymphoma (NHL) was treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT). Although he had HLA-DRB1 0405 and a positive rheumatoid factor, he was unlikely to develop rheumatoid arthritis (RA) according to diagnostic criteria. However, the patient developed RA 40 days after transplantation. Our experience suggests that the systemic autoimmune disease, RA, may occur in patients with predisposing factors after autologous PBSCT.

show abstract

Allogeneic bone marrow transplantation from a donor with severe active rheumatoid arthritis not resulting in adoptive transfer of disease to recipient

Cited by 35 publications

References 1 publication

Long‐term outcome of autoimmune disease following allogeneic bone marrow transplantation

Long‐term outcome of autoimmune disease following allogeneic bone marrow transplantation

Adoptive autoimmune hyperthyroidism following allogeneic stem cell transplantation from an HLA-identical sibling with Graves’ disease

Development of rheumatoid arthritis following autologous peripheral blood stem cell transplantation

Contact Info

Product

Resources

About