Allogeneic Bone Marrow Transplantation for Acute Lymphoblastic Leukemia During First Complete Remission

The role of allogeneic bone marrow transplantation in adult patients below the age of 55 years with acute lymphoblastic leukemia in first complete remission: a donor vs no donor comparison

“…13 Various transplant series have described a better long-term survival with alloBMT as postremission therapy. 15,16 The main shortcomings of these studies are related to patient selection bias, small numbers of patients and exclusion of patients whose remission is too short to allow transplant in CR1. Based on genetic randomization, comparison of alloBMT (n ¼ 116) was done with the control group (n ¼ 141, treated with chemotherapy or autologous BMT) in CR1 in a multicenter study (LALA 87) involving 43 French and Belgian centers.…”

Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison

“…The remaining patients are considered standard-risk patients. Allogeneic hematopoietic stem cell transplantation (allo-SCT) has been established as an effective treatment modality to reduce the risk of relapse in adults with ALL in first complete remission (CR1), [6][7][8][9][10][11][12][13][14][15] but treatment-related mortality (TRM) may counterbalance that favorable effect. As a result, it has been difficult to demonstrate improved overall outcome in the context of prospective studies.…”

Long-term follow-up of 23 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with allogeneic bone marrow transplant in first complete remission

“…5 Allogeneic bone marrow transplantation (BMT) has been utilized as a post-induction therapy to try to improve disease-free survival (DFS) for these patients. 6 The IBMTR has reported a 38% disease-free survival rate for patients transplanted with Ph+ ALL in first CR. 7 The bcr-abl oncogene, which is the molecular counterpart of the Ph chromosome, is detected in two variant forms, either p190 or p210, by sensitive polymerase chain reaction (PCR) techniques.…”