Allogeneic blood transfusion reduces murine pulmonary natural killer (NK) activity and enhances lung metastasis of a syngeneic tumour

Clarke, Philip; Burton, Robert C.; Wood, Kathryn J.

doi:10.1002/ijc.2910550620

Cited by 12 publications

(10 citation statements)

References 22 publications

(13 reference statements)

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“…An adverse effect of blood transfusion on natural killer and T-lymphocyte function might also be associated with changes in cancer behavior [32,33] . Using an in vivo experimental system, Clarke et al [34] concluded that suppression of natural killer cell activity by allogeneic blood transfusion augments metastasis. With the aim of minimizing transfusion-associated immunomodulatory effects that induce increased morbidity and poor prognosis in cancer patients, transfusion of leukocyte-depleted packed red blood cells has been studied.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Blood Transfusion, Age at Surgery, and Prognosis in a Database of 526 Upper Gastrointestinal Cancers

Kosumi

Baba²,

Harada³

et al. 2015

Dig Surg

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Aims: It is demonstrated that older animals have significantly weaker responses to new alloantigen stimulation than young animals, but the effect on prognosis of perioperative blood transfusion in relation to patient age is unknown. This study is retrospective review to investigate the relationship between perioperative blood transfusion, age at surgery, and clinical outcome in upper gastrointestinal cancer patients. Methods: We analyzed data of 526 upper gastrointestinal cancer patients who underwent curative resection from 2005 to 2010. Results: In esophageal cancer patients, patients with blood transfusion experienced significantly shorter overall survival (OS; univariate HR 2.50, p = 0.0006) and disease-free survival (DFS; univariate HR 1.71, p = 0.016) than patients without. Similar results were observed in gastric cancer patients (OS; univariate HR 3.35, p = 0.0001 and DFS; univariate HR = 3.18, p < 0.0001). Furthermore perioperative blood transfusion may be an independent prognostic factor in esophageal cancer patients (multivariate HR = 2.07, p = 0.026). Interestingly, age at surgery significantly affected the influence of blood transfusion on patient outcome in esophageal cancer patients (p for interaction = 0.022). Conclusion: The negative effect of perioperative blood transfusion was particularly evident among younger patients with esophageal cancer.

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Section: Discussionmentioning

confidence: 99%

Perioperative Blood Transfusion, Age at Surgery, and Prognosis in a Database of 526 Upper Gastrointestinal Cancers

Kosumi

Baba²,

Harada³

et al. 2015

Dig Surg

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“…Nonspecific cytotoxic lymphocytes as well as macrophages play important roles in the prevention of lymph node and distant metastases [14]. The inhibition of metastasis by these cells must be thoroughly investigated in order to explore the mechanism of metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…It is well recognized that tumor cell metastasis is under the regulation of the cellular immunity of the host [5, 14, 15]. Nonspecific cytotoxic lymphocytes as well as macrophages play important roles in the prevention of lymph node and distant metastases [14].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Metastasis in Oral Squamous Cell Carcinomas

Osaki¹,

Kimura²,

Tatemoto³

et al. 2000

Oncology

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Lymph node and distant metastasis were comparatively studied in 225 oral carcinomas, and factors predisposing toward metastasis were investigated using clinical and immunohistopathological approaches. Neither the sites of tumors nor T-stage was correlated with either type of metastasis. Tumor cell differentiation was weakly correlated with lymph node metastasis, and stromal reaction (the degree of cell infiltration) did not differ greatly between metastasis-positive and negative tumors, although natural killer (NK) activities were correlated with lymph node metastasis. However, the mode of tumor cell invasion was closely associated with both lymphnode and distant metastases. In grade 4C and 4D tumors, distant and lymph node metastases were observed in 8 (16%) and 31 (62%) cases, respectively, while of 68 grade 1 and 2 tumors, distant metastasis was not observed in any, and lymph node metastasis occurred in only 15 (22.1%). In addition, the expression of p53 protein was correlated with lymph node metastasis; of 70 tumors without p53 protein expression, 23 (32.9%) revealed lymph node metastasis, while it occurred in 54 out of 96 tumors positive for p53 protein. However, p53 protein expression was not associated with distant metastasis, and p24 protein, a cyclin-dependent kinase inhibitor, did not show any relationship with either type of metastasis. These results indicate that lymph node metastasis is correlated with multiple factors in the host and tumor cells, but distant metastasis is only correlated with the mode of tumor cell invasion, suggesting that the former can be highly accurately predicted by invasion mode, p53 protein expression and NK activity.

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“…Most data emerged from animal studies, where the level of NK activity was correlated with tumor progression [38,39,43,44]. However, a study in humans also showed that pre operative NK activity correlated with an increased risk of tumor recurrence [32], It has recently been shown that in colorectal cancer patients, disseminated tumor cells found at curative surgery of even early tumor stages demonstrated a prognostic impact [45].…”

Section: Blood Transfusion and Nk And Lak Activitiesmentioning

confidence: 99%

“…The effect on NK activity has been investigated, both ex perimentally [38,39] and clinically [29,30,34,40,41]. Most authors report a transfusion-associated NK suppres sion which, however, was not seen in two studies [31,42].…”

Section: Modulation By Autologous Blood Transfusionmentioning

confidence: 99%

Influence of Autologous Blood Transfusion on Natural Killer and Lymphokine-Activated Killer Cell Activities in Cancer Surgery

Jauch¹,

Schildberg²,

Heiss³

et al. 1997

Vox Sanguinis

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Background and objectives: Immunosuppression associated with blood transfusion may influence postoperative infection rates. It may also affect the prognosis of patients treated surgically for colorectal cancer. To control this effect, study protocols have applied autologous blood donation programs, which are thought to be immunologically neutral. However, evidence has emerged that blood donation itself might have suppressive effects on natural killer (NK) cell activities. At present, there are no data available on the effects of autologous blood transfusion on NK or lymphokine-activated killer (LAK) cells. This might be of interest as LAK cells may be active in tumor control. Materials and methods: 26 patients who underwent surgical resection for colorectal cancer, were assigned at random into two groups: (1) autologous blood donation and transfusion, or (2) allogeneic blood transfusion. NK and LAK activities were determined before blood donation, at surgery, and on the 3rd and 8th postoperative day. Results: Blood donation induced a small decrease in NK and LAK activities. The postoperative courses of the two groups differed. In the allogeneic group, NK activity (-50%, p = 0.018) and LAK activity decreased (-60.7%, p = 0.043), whereas in the autologous group the decline in LAK was less pronounced (-33.7%, p = 0.091), and their NK activity even increased (+17.4%, p = 0.315). NK activity was modulated differently in the two study groups (0.0036). Differences in LAK activities were found between the 3rd and 8th day postoperatively (p = 0.354). Conclusions: In patients receiving autologous blood transfusion, postoperative suppressed NK and LAK activities were modulated. This implies that autologous blood transfusion is not immunologically neutral, but has an intrinsic immunomodulatory potential.

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Allogeneic blood transfusion reduces murine pulmonary natural killer (NK) activity and enhances lung metastasis of a syngeneic tumour

Cited by 12 publications

References 22 publications

Perioperative Blood Transfusion, Age at Surgery, and Prognosis in a Database of 526 Upper Gastrointestinal Cancers

Perioperative Blood Transfusion, Age at Surgery, and Prognosis in a Database of 526 Upper Gastrointestinal Cancers

Risk Factors of Metastasis in Oral Squamous Cell Carcinomas

Influence of Autologous Blood Transfusion on Natural Killer and Lymphokine-Activated Killer Cell Activities in Cancer Surgery

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