Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors

Abstract

Because of the rather short observation period. secondary malignant neoplasms (SMN) may complicate the future clinical course of some of our patients who are currently viewed as event-free survivors. EFS in AET is not improved by allogeneic SCT due to a higher complication rate. The patient group was to small to analyze for a possible graft-versus-tumor effect.

Total body MRI-governed involved compartment irradiation combined with high-dose chemotherapy and stem cell rescue improves long-term survival in Ewing tumor patients with multiple primary bone metastases

“…Eleven group A patients with high-risk ET-MBM were treated from 1995 to 2000 according to the Meta-EICESS protocols as previously described 19,20 (Figure 1). These patients received ICI on the basis of TB-MRI at initial staging.…”

“…Finally, within the high-risk group of patients with primary multifocal bone or BM disease, a higher number of involved bones worsened the prognosis: no patient with more than one bone or with BM metastasis survived in this study. 10,20 Taken together, metastatic ETs are heterogeneous, and even within ET-MBM prognosis may vary depending on the number of involved bones. In this study, we addressed patients with more than one (multiple) metastatic bone, with or without BM metastases at diagnosis.…”

“…19,20 A respective treatment overview is shown in Figure 1. All 11 patients received TB-MRI as a part of the initial staging procedure.…”

“…The data of these patients have been published previously with short-term follow-up. 19,20 In group B, 26 patients with more than three bones involved at diagnosis (aged 6-37 years; median: 17 years) were registered from 1992 to 1996 and treated according to the European Intergroup Cooperative Ewing Sarcoma Study 92 protocol (EICESS 92) for high-risk ET-MBM, as previously described. 21 In all, 1 out of 26 patients had LN metastases and 10 out of 26 patients had lung disease at initial diagnosis.…”

Segregated graft-versus-tumor effect between CNS and non-CNS lesions of Ewing's sarcoma family of tumors

“…3,4 Therefore, a new and more effective treatment approach is clearly needed for this population. Several reports have described patients with ESFT who had bone marrow metastases and underwent allogeneic SCT instead of autologous SCT, 5 including a rare patient who exhibited evidence of a graftversus-tumor (GVT) effect. 6 To accumulate further knowledge, we report the case of a patient with recurrent ESFT who responded to allogeneic SCT from a sibling donor.…”