Allocentric spatial neglect with posterior cortical atrophy

Zilli, Eduardo M.; Heilman, Kenneth M.

doi:10.1080/13554794.2013.878731

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…These deficits may occur as part of a Gerstmann syndrome (agraphia, acalculia, left-right disorientation, and finger agnosia) or may be isolated. Attentional disorders may occur as visual ( 16 , 45 ) or spatial neglect ( 46 ) or a combination of the two. Ideomotor apraxia is not rare, but it is usually mild in early stages, and if prominent should raise the suspicion of an alternative diagnosis, such as CBD.…”

Section: Clinical Profilementioning

confidence: 99%

Visual Dysfunction in Posterior Cortical Atrophy

et al. 2017

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Posterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer pathology. The aim of this review is to summarize the development of the concept of this disorder since it was first introduced. A critical discussion of the evolving diagnostic criteria is presented and the differential diagnosis with regard to the underlying pathology is reviewed. Emphasis is given to the visual dysfunction that defines the disorder, and the classical deficits, such as simultanagnosia and visual agnosia, as well as the more recently recognized visual field defects, are reviewed, along with the evidence on their neural correlates. The latest developments on the imaging of PCA are summarized, with special attention to its role on the differential diagnosis with related conditions.

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Section: Clinical Profilementioning

confidence: 99%

Visual Dysfunction in Posterior Cortical Atrophy

et al. 2017

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“…PCA is associated with atrophy in the occipital, parietal, and posterior temporal lobes [106], but recently a lesion of long white-matter tracts, including the superior and inferior longitudinal fasciculi and the inferior fronto-occipital fasciculus, has also been documented [107]. This early-onset AD-related pathology gives rise to complex visuospatial difficulties, such as visuoperceptual impairments [108], optic ataxia, simultanagnosia, gaze apraxia (often with the complete spectrum of Balint syndrome), and even egocentric [109,110] or allocentric [111] unilateral spatial neglect. All such visuospatial impairments have a strong impact on drawing abilities, affecting both spontaneous drawing and copying, and giving rise to severe displacements of drawing elements, omissions, gross spatial distortions ('exploded drawings') [112].…”

Section: Drawing Disabilities In Early and Late Onset Forms Of Admentioning

confidence: 99%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

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Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

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“…Unilateral neglect refers to the inability to report or respond to the stimulus presented on the side contralateral to the lesioned hemisphere, which cannot be accounted for by motor or sensory deficits [1,2]. Unilateral neglect can follow tumor [3], trauma [4], or neurodegenerative disease [5,6], but it occurs most commonly after stroke, especially right‐hemispheric stroke [7,8]. Stroke is the third leading cause of disability and the second most common cause of death worldwide [9].…”

Section: Introductionmentioning

confidence: 99%

Mirror therapy for unilateral neglect after stroke: A systematic review

Zhang

Xing

et al. 2021

Euro J of Neurology

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Background and purpose The effect of mirror therapy for unilateral neglect after stroke currently remains uncertain. Methods This systematic review investigated the effect of mirror therapy on neglect and daily living activities in patients with unilateral neglect after stroke when compared with no treatment, sham mirror therapy, or routinely applied therapies only. We performed a systematic electronic search of PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, and Wanfang Data to identify relevant randomized control trials (RCTs). Results We included five RCTs in the data synthesis. Mirror therapy (combined or not with other treatments) was more effective in improving neglect as compared with sham mirror therapy or no treatment (combined or not with the other therapies; standard mean difference [SMD] = 1.62, 95% confidence interval [CI] = 1.03–2.21, p < 0.00001). Mirror therapy (combined or not with other therapies) was effective in improving daily living activities as compared with sham mirror therapy or no treatment (combined or not with the other therapies; SMD = 2.09, 95% CI = 0.63–3.56, p = 0.005). Conclusions Our results show that mirror therapy effectively improves neglect and daily living activities in patients with unilateral neglect after stroke. Future trials with high methodological quality and larger sample sizes are needed to determine the immediate and long‐term effect of appropriate mirror therapy protocol for unilateral neglect.

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Allocentric spatial neglect with posterior cortical atrophy

Cited by 9 publications

References 45 publications

Visual Dysfunction in Posterior Cortical Atrophy

Visual Dysfunction in Posterior Cortical Atrophy

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Mirror therapy for unilateral neglect after stroke: A systematic review

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