Allocation of Vascularized Composite Allografts

Cendales, Linda C.; Rahmel, Axel; Pruett, Timothy L.

doi:10.1097/tp.0b013e31824b073f

Cited by 22 publications

(9 citation statements)

References 3 publications

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“…Bu noktada doku tahsis sistemleri ve ameliyat sahaları bu kompleks ilemi yapabilecek belirli merkezlerde olmalıdır. [22] rejeksiyon u anda dört önemli engel, VKA kullanımını sınırlamaktadır. Birincisi "akut rejeksiyon"dir.…”

Section: Nak‹l Seç‹m Kr‹terler‹unclassified

Solid organ transplantation and vascularized composite allotransplantation: Past and present

Erçin¹

2017

FNG & Bilim Tıp Transplantasyon Dergisi

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There has not only been improvements in clinical aspects for vascularized composite allotransplantation, which is new and experimental compared to solid organ transplantation. In this review, we compiled the achievements obtained and the failures after clinical applications, accompanied with the explanations of experimental studies that are supposed to support them or solve their problems. Following these parallel experimental and clinical studies, recipient-donor criteria, rejection staging and rejection preventive treatments were researched as in solid organ transplantation and are still being investigated. In the last 20 years, clinical practices and studies have been very encouraging. While solid organ transplantation is the gold standard treatment for most patients with advanced organ failure, vascularized composite allotransplantation can be considered as a complementary option in cases where it is not possible to remedy the patients with their own tissues in patients with physical and psychosocial deficits after extremity loss. In this review, we examined the differences and similarities in terms of indications, side effects, rejection, patient and graft survival in vascular composite and solid organ allotransplantation, and their development in recent years.

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Section: Nak‹l Seç‹m Kr‹terler‹unclassified

Solid organ transplantation and vascularized composite allotransplantation: Past and present

Erçin¹

2017

FNG & Bilim Tıp Transplantasyon Dergisi

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“…Instead of using surrogate parameters like age and gender for matching, specific phenotypic matching based on size, especially concerning bones, color and texture of the skin, and soft tissue features has been recommended by several authors [ 25 , 32 ••, 57 ]. Organ-specific parameters have to be defined to allow adequate anthropometric measurements and the corresponding matching.…”

Section: Allocationmentioning

confidence: 99%

Vascularized Composite Allografts: Procurement, Allocation, and Implementation

Rahmel

2014

Curr Transpl Rep

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Vascularized composite allotransplantation is a continuously evolving area of modern transplant medicine. Recently, vascularized composite allografts (VCAs) have been formally classified as ‘organs’. In this review, key aspects of VCA procurement are discussed, with a special focus on interaction with the procurement of classical solid organs. In addition, options for a matching and allocation system that ensures VCA donor organs are allocated to the best-suited recipients are looked at. Finally, the different steps needed to promote VCA transplantation in society in general and in the medical community in particular are highlighted.

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“…In March 2008, the Health Resources and Services Administration (HRSA) of the HHS published a Request for Information in the Federal Register requesting feedback on whether VCAs should be included within the OPTN Final Rule’s definition of organs. Public comment on modifications to the OPTN Final Rule was sought and the Code of Federal Regulation was amended in December 2011. Modifications to the OPTN Final Rule adding VCA to the definition of “covered human organs” were effective on July 3, 2014 …”

Section: Introductionmentioning

confidence: 99%

Vascularized composite allotransplantation in the United States: A descriptive analysis of the Organ Procurement and Transplantation Network Data

Cherikh¹,

Cendales

Wholley³

et al. 2019

American Journal of Transplantation

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On July 3, 2014, the Organ Procurement and Transplantation Network/United Network for Organ Sharing was charged with the oversight of vascularized composite allograft (VCA) procurement and transplantation in the United States. As of December 31, 2017, 61 VCA programs at 27 centers were approved in the United States. Fifty candidates have been added to the waiting list at 15 centers. Twenty-eight VCA transplants have been performed at 14 programs (10 upper limb, 10 uterus, 5 craniofacial, 1 scalp, 1 abdominal wall, and 1 penile). Twenty-two VCAs were procured from 21 deceased donors, resulting in 109 non-VCA organs transplanted (15 hearts, 3 intestine, 40 kidney, 20 livers, 24 lungs, and 7 pancreata). Six uterus transplants were performed from living donors. Fourteen candidates were still waiting at 9 centers on December 31, 2017. Two of the 10 uterus recipients had live births and 3 still had viable grafts. Seventeen of 18 nonuterus recipients had functioning grafts. At present, VCA is an emerging field with a small number of patients transplanted. Data on posttransplant survival and functional outcomes continue to be collected to further the understanding of this complex and evolving field. Further systematic data are important for policy refinement and assurance of patient safety.

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Allocation of Vascularized Composite Allografts

Cited by 22 publications

References 3 publications

Solid organ transplantation and vascularized composite allotransplantation: Past and present

Solid organ transplantation and vascularized composite allotransplantation: Past and present

Vascularized Composite Allografts: Procurement, Allocation, and Implementation

Vascularized composite allotransplantation in the United States: A descriptive analysis of the Organ Procurement and Transplantation Network Data

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