Abstract:Allospecific NK cell hyporesponsiveness develops after in utero hematopoietic cellular transplantation (IUHCT) in mice who exhibit stable long-term engraftment. Conversely, allospecific NK cell responses are normal in mice that reject their graft. We hypothesized that these alternate NK cell responses also differentially influence T cell responses after IUHCT.
To challenge this hypothesis, we compared the helper or suppression potential of prenatally educated NK cells between prenatal recipients… Show more
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