Allicin prevents the formation of Proteus-induced urinary crystals and the blockage of catheter in a bladder model in vitro

Rad, Hamed Imani; Peeri, Hadi; Amani, Mojtaba; Mohammadnia, Alireza; Ogunniyi, Abiodun D.; Khazandi, Manouchehr; Venter, Henrietta; Arzanlou, Mohsen

doi:10.1016/j.micpath.2019.05.016

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…All of the equipment was assembled to simulate the human urinary bladder system. Some of the selected literature established in vitro bladder models based on the same models or with some modifications [two bladder models (13,15) were modified from the model reported by Abbott et al (21); eight bladder models (16,17,19,30,32,33,35,38) were modified from the model reported by Stickler et al (49); two bladder models (32,39) were modified from the model reported by Gaonkar et al (43); one bladder model (28) was modified from the model reported by Fu et al (36); two bladder models (31,34) was modified from the model reported by Andersen et al (37); one bladder model (45) was modified from the model reported by Stickler et al (55); one bladder model (48) was modified from the model reported by Getliffe et al (59); six bladder models (19,41,(50)(51)(52)(53) were modified from the model reported by Stickler et al (58); one bladder model ( 62) was modified from the model reported by Stickler et al (64); 11 bladder models (63,(65)(66)(67)(68)(69)(70)72,73,…”

Section: Model Construction and Analysismentioning

confidence: 99%

“…Forty-five studies were conducted to explore bacterial biofilm formation in bladder models, which corresponds with the current research focus. A total of 36 studies were performed with comparative experimental designs, mainly consisting of comparisons between various coatings of drugs or different materials, including between static and dynamic models in three studies (20,27,30), the comparative analysis of culture fluids in two studies (56,57), comparisons between multiple interventions in 21 studies (13,14,(17)(18)(19)(20)22,(28)(29)(30)36,38,39,41,43,50,(53)(54)(55)58,64), comparisons between infection vectors in eight studies (37,40,42,44,45,52,53,58), and comparisons between experimental temperature in one study (37).…”

Section: Research Design and Content Analysismentioning

confidence: 99%

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In vitro dynamic bladder models for studying urinary tract infections: a narrative review

Xiong¹,

Xie²,

Liu³

2021

Ann Palliat Med

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Experimental models of the bladder are key to studying the pathogenic mechanism of catheterrelated bacterial biofilm infection. Although numerous studies have reported multiple models, these model designs were heterogeneous. This study aimed to review the status quo and explore the problems associated with in vitro dynamic bladder models for studying urinary tract infections (UTIs). The PubMed and SinoMed databases were searched from their inception to February 2020. Studies regarding in vitro bladder models related to UTIs were reviewed based on a bibliometric evaluation of their basic characteristics and model analysis. A total of 74 papers and 44 bladder models were included in this study. The results were as follows: (I) urine transmission devices: 10 studies applied the gravity effect of culture media, while the others used peristaltic pumps, and 11 of them combined stirring or rotating forces. The flow rates in all studies ranged from 15 µL/min to 50 mL/min. (II) Bladder model: two studies reported on simulating the bladder using plastic bags, while the others reported on glass cylinders or fermenters with a capacity of 200 to 700 mL. E. coli and P. mirabilis were the main bacterial strains. (III) Infection carrier: six studies reported planktonic bacteria as their infection carrier, while 45 studies reported silica gel, rubber, polyurethane, silicone, polytetrafluoroethylene, or perfusion bag. (IV) Infection medium: 25 studies reported the culture medium. Thirty-two studies reported artificial urine, while 17 studies reported human urine. (V) Research analysis: 45 studies investigated the bacterial biofilm formation in the bladder model. Thirty-six studies compared the effects of various drug coatings, diverse material surfaces, or different materials. Only five studies compared distinct bladder models. The included studies' main defects were the single simulation of bladder urodynamics, divers parameter settings, and non-standard experimental modeling. Our analysis showed for the first time that in vitro dynamic bladder models could provide new ideas for exploring the mechanism and prevention of bacterial biofilm infection in urinary implanted biomaterials. Due to the limitations of the included studies, more high-quality studies are needed to verify the conclusions above further.

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Section: Model Construction and Analysismentioning

confidence: 99%

Section: Research Design and Content Analysismentioning

confidence: 99%

In vitro dynamic bladder models for studying urinary tract infections: a narrative review

Xiong¹,

Xie²,

Liu³

2021

Ann Palliat Med

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Ureases as drug targets in urinary tract infections

Deutch

2024

Ureases

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Advances in experimental bladder models: bridging the gap between in vitro and in vivo approaches for investigating urinary tract infections

Nissanka,

Dilhari,

Wijesinghe

et al. 2024

BMC Urol

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Urinary tract infections (UTIs) pose a substantial burden on global healthcare systems. When unraveling the complex pathophysiology of UTIs, bladder models are used to understand complex and multifaceted interactions between different components within the system. This review aimed to bridge the gap between in vitro and in vivo experimental bladder models towards UTI research. We reviewed clinical, animal, and analytical studies and patents from 1959 to the end of 2023. Both in vivo and in vitro models offer unique benefits and drawbacks in understanding UTIs. In vitro models provide controlled environments for studying specific aspects of UTI biology and testing potential treatments, while in vivo models offer insights into how UTIs manifest and progress within living organisms. Thus, both types of models are leading to the development of more effective diagnostic tools and therapeutic interventions against UTIs. Moreover, advanced methodologies involving three-dimensional bladder organoids have also been used to study bladder biology, model bladder-related disorders, and explore new treatments for bladder cancers, UTIs, and urinary incontinence. Narrowing the distance between fundamental scientific research and practical medical applications, these pioneering models hold the key to unlocking new avenues for the development of personalized diagnostics, precision medicine, and ultimately, the alleviation of UTI-related morbidity worldwide.

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Allicin prevents the formation of Proteus-induced urinary crystals and the blockage of catheter in a bladder model in vitro

Cited by 4 publications

References 38 publications

In vitro dynamic bladder models for studying urinary tract infections: a narrative review

In vitro dynamic bladder models for studying urinary tract infections: a narrative review

Ureases as drug targets in urinary tract infections

Advances in experimental bladder models: bridging the gap between in vitro and in vivo approaches for investigating urinary tract infections

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