Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α

Lee, Chung Gi; Lee, Hee-Weon; Kim, Byung-Oh; Rhee, Dong‐Kwon; Pyo, Suhkneung

doi:10.1016/j.jff.2015.03.017

Cited by 26 publications

(13 citation statements)

References 54 publications

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“…Several studies have shown that garlic has numerous biological properties, (Fujisawa, Suma, Origuchi, Seki, & Ariga, 2008;Iciek, Kwiecien, & Wlodek, 2009;Lee, Lee, Kim, Rhee, & Pyo, 2015;Santhosha, Jamuna, & Prabhavathi, 2013) due to the presence of phytochemicals, which make garlic a healthy food. These compounds include organosulphur compounds (OSCs) that are synthesized using sulphate absorbed by roots as a source of sulphur.…”

Section: Introductionmentioning

confidence: 99%

Home-cooked garlic remains a healthy food

Locatelli

Altamirano

González

et al. 2015

Journal of Functional Foods

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Section: Introductionmentioning

confidence: 99%

Home-cooked garlic remains a healthy food

Locatelli

Altamirano

González

et al. 2015

Journal of Functional Foods

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“…Studies have also shown that allicin induces apoptosis in leukemiaderived cells through the depletion of cellular glutathione (GSH) and modulation of the cellular redox state [28] , as well as significantly increasing reactive oxygen species (ROS) production in liver cancer, leading to reduced mitochondrial membrane potential, apoptosis, and cell death [29] . Additionally, allicin and saturated short-chain thiosulfinate analogs are known to act on intracellular calpain, inhibiting invasion and migration in cancer cells [30] . This activity inhibits the release of microparticles (MPs), which have been shown to transfer P-gp from MDR cells to drug-sensitive cells [31,32] .…”

Section: Introductionmentioning

confidence: 99%

“…This activity inhibits the release of microparticles (MPs), which have been shown to transfer P-gp from MDR cells to drug-sensitive cells [31,32] . These findings make these compounds attractive leads in targeting proliferation, metastasis and MDR in cancer [30,[32][33][34] . Importantly, allicin and thiosulfinate derivatives have been shown to be cancerspecific while being non-toxic to normal cells and have been reported to increase survival times in tumor-bearing mice [35,36] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vitro biological evaluation of thiosulfinate derivatives for the treatment of human multidrug-resistant breast cancer

2017

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Organosulfur compounds derived from Allium vegetables have long been recognized for various therapeutic effects, including anticancer activity. Allicin, one of the main biologically active components of garlic, shows promise as an anticancer agent; however, instability makes it unsuitable for clinical application. The aim of this study was to investigate the effect of stabilized allicin derivatives on human breast cancer cells in vitro. In this study, a total of 22 stabilized thiosulfinate derivatives were synthesized and screened for their in vitro antiproliferative activities against drug-sensitive (MCF-7) and multidrug-resistant (MCF-7/Dx) human adenocarcinoma breast cancer cells. Assays for cell death, apoptosis, cell cycle progression and mitochondrial bioenergetic function were performed. Seven compounds (4b, 7b, 8b, 13b, 14b, 15b and 18b) showed greater antiproliferative activity against MCF-7/Dx cells than allicin. These compounds were also selective towards multidrug-resistant (MDR) cells, a consequence attributed to collateral sensitivity. Among them, 13b exhibited the greatest anticancer activity in both MCF-7/Dx and MCF-7 cells, with IC values of 18.54±0.24 and 46.50±1.98 μmol/L, respectively. 13b altered cellular morphology and arrested the cell cycle at the G/M phase. Additionally, 13b dose-dependently induced apoptosis, and inhibited cellular mitochondrial respiration in cells at rest and under stress. MDR presents a significant obstacle to the successful treatment of cancer clinically. These results demonstrate that thiosulfinate derivatives have potential as novel anticancer agents and may offer new therapeutic strategies for the treatment of chemoresistant cancers.

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“…There are a number of studies demonstrating that garlic can reduce various types of diseases such as anticancer, antidiabetic, anti-inflammatory, antimicrobial, antioxidant, cardioprotective, and immunomodulatory activities [10][11][12][13][14]. Using modern scientific techniques, the biological effects of garlic have been studied for decades.…”

Section: Introductionmentioning

confidence: 99%

Perspective of garlic processing wastes as low‐cost substrates for production of high‐added value products: A review

Kallel

Châabouni

2017

Env Prog and Sustain Energy

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The large amounts of solid biological wastes produced in industrial activities increases production costs. As a consequence, it is common to develop strategies to reuse these wastes by transforming them for usage in other processes/industries. This paper is the first paper examining the use of garlic by‐products as bioresource. This study delineates firstly the physicochemical and biological characterization of garlic by‐products such as straw and peels, secondly provides the various applications of garlic by‐products in different domains and unveils their potential for industrial applications such as feed alimentation, soil amendment and bioenergy. They presented potential exploitation as bioadsorbents for wastewater treatment. Finally, these by‐products could be exploited for further industrial purposes such as extraction of bioactive components and extraction of functional ingredients and production of phenolic compounds and biofuel such as biogas and bio‐oil. © 2017 American Institute of Chemical Engineers Environ Prog, 36: 1765–1777, 2017

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Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α

Cited by 26 publications

References 54 publications

Home-cooked garlic remains a healthy food

Home-cooked garlic remains a healthy food

Synthesis and in vitro biological evaluation of thiosulfinate derivatives for the treatment of human multidrug-resistant breast cancer

Perspective of garlic processing wastes as low‐cost substrates for production of high‐added value products: A review

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