Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia

Liu, De‐Shan; Wang, Shuli; Li, Junmei; Liang, Er-shun; Yan, Ming‐Zhong; Gao, Wei

doi:10.3892/etm.2017.4698

Cited by 23 publications

(26 citation statements)

References 32 publications

(19 reference statements)

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“…Several studies have reported the beneficial effects of garlic in different presentations, such as extracts, lyophilization, and pills. Allicin has demonstrated a plethora of beneficial effects [66][67][68], but the dose used in experimental models, as well as in patients, is between 10 and 40 mg/day, and no secondary effects have been described. However, the use of allicin in patients is limited and focused on triglycerides and cholesterol alterations.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of Allicin Associated with Fibrosis in Pulmonary Arterial Hypertension

Sánchez-Gloria

Martínez-Olivares

Rojas-Morales

et al. 2021

IJMS

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Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling. Recent evidence supports that inflammation plays a key role in triggering and maintaining pulmonary vascular remodeling. Recent studies have shown that garlic extract has protective effects in PAH, but the precise role of allicin, a compound derived from garlic, is unknown. Thus, we used allicin to evaluate its effects on inflammation and fibrosis in PAH. Male Wistar rats were divided into three groups: control (CON), monocrotaline (60 mg/kg) (MCT), and MCT plus allicin (16 mg/kg/oral gavage) (MCT + A). Right ventricle (RV) hypertrophy and pulmonary arterial medial wall thickness were determined. IL-1β, IL-6, TNF-α, NFкB p65, Iкβ, TGF-β, and α-SMA were determined by Western blot analysis. In addition, TNF-α and TGF-β were determined by immunohistochemistry, and miR-21-5p and mRNA expressions of Cd68, Bmpr2, and Smad5 were determined by RT-qPCR. Results: Allicin prevented increases in vessel wall thickness due to TNF-α, IL-6, IL-1β, and Cd68 in the lung. In addition, TGF-β, α-SMA, and fibrosis were lower in the MCT + A group compared with the MCT group. In the RV, allicin prevented increases in TNF-α, IL-6, and TGF-b. These observations suggest that, through the modulation of proinflammatory and profibrotic markers in the lung and heart, allicin delays the progression of PAH.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of Allicin Associated with Fibrosis in Pulmonary Arterial Hypertension

Sánchez-Gloria

Martínez-Olivares

Rojas-Morales

et al. 2021

IJMS

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“…The lipid-lowering, anti-inflammatory, and antioxidative properties are underlying its atheroprotective Targeting Foam Cells by Natural Products effects observed in hyperlipidemic mice and rabbits (Abramovitz et al, 1999;Gonen et al, 2005;Yokoyama et al, 2012). Importantly, allicin (40 mg 3 times daily for 12 weeks) also decreased the carotid intima/media thickness in CAD patients with hyperhomocysteinemia (Liu et al, 2017a). A recent study (Lin et al, 2017) also showed that allicin reduced the TC, FC, and CE levels in THP-1 macrophage-derived foam cells by upregulating the ABCA1-dependent cholesterol efflux via PPARg/ LXRa signaling pathway.…”

Section: G Fatty Acidsmentioning

confidence: 97%

“…Decreased carotid intima/media thickness, decreased homocysteine, TC, and TG in CAD patients with hyperhomocysteinemia (Liu et al, 2017a). Pyranone derivatives: Asperlin Promoted cholesterol efflux from mouse macrophages (Zhou et al, 2017).…”

Section: Namentioning

confidence: 99%

Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

et al. 2019

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“…Color Doppler ultrasonography is a simple, non-invasive, economical and reproducible tool for the assessment of carotid atherosclerosis (16), and can directly measure the IMT in the absence of changes in hemodynamics an d morphology. Thus, it can predict and detect the early vascular changes in T2DM patients and therefore has been widely used for the assessment of systemic atherosclerosis and cardiovascular risk in adults (17). In this study, on the basis of arteriosclerosis scores, plaque size, PSV and EDV, our results indicated that atherosclerosis is a progressive process in T2DM, even with drug treatment, and treatment is to delay its progression and deterioration.…”

Section: Psv and Edvmentioning

confidence: 56%

Anti-atherosclerotic effects between a combined treatment with simvastatin plus hirudin and single simvastatin therapy in patients with early type 2 diabetes mellitus

Li¹,

Lv²,

Li³

et al. 2019

Ann. Transl. Med.

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Background: This study aimed to investigate the efficacy and safety of simvastatin plus hirudin in preventing atherosclerosis in the patients with early type 2 diabetes mellitus (T2DM). Methods: This was a 24-week, randomized, open-label and controlled study in which 150 outpatients initially diagnosed with T2DM were randomly assigned into either simvastatin (40 mg daily at night) plus hirudin (3 g thrice daily) group [combined group (CG) n=75] or simvastatin (40 mg once daily) group [monotherapy group (MG) n=75]. The therapeutic efficacy was evaluated by the score of carotid artery atherosclerosis, plaque size, peak systolic velocity (PSV) and end-diastolic velocity (EDV) on carotid ultrasonography at three and six months after treatment. Logistic regression analysis was used to investigate the correlation between treatment and carotid atherosclerosis. Results: One hundred and thirty-one patients completed this study, and there were no significant differences in the dropout rate in the CG (14.67%) and the MG (10.67%). Significant difference was found in the incidence of adverse events in the CG compared with the MG (37.50% vs. 17.91%, P<0.05) due to the higher risk of hemorrhage (12.50% vs. 1.49%, P<0.05), which did not affect the treatment compliance. The efficacy of combined treatment was better than monotherapy in the enhancement of carotid artery atherosclerosis scores (P<0.01), the plaque thickness (P<0.05) and the change of PSV (P<0.05) and EDV (P<0.05) since three months after treatment, which maintained to the end of observation. In addition, hirudin treatment was able to independently predict the carotid artery atherosclerosis scores (β=2.37, P<0.05), the plaque thickening (β=3.51, P<0.01) and the change of PSV (β=1.69, P<0.05) and EDV (β=1.79, P<0.05). Conclusions: Combined use of simvastatin and hirudin is well tolerated and possesses better antiatherosclerotic effects than simvastatin alone in patients with early T2DM.

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Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia

Cited by 23 publications

References 32 publications

Anti-Inflammatory Effect of Allicin Associated with Fibrosis in Pulmonary Arterial Hypertension

Anti-Inflammatory Effect of Allicin Associated with Fibrosis in Pulmonary Arterial Hypertension

Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products

Anti-atherosclerotic effects between a combined treatment with simvastatin plus hirudin and single simvastatin therapy in patients with early type 2 diabetes mellitus

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