Allgemeine Grundlagen

Fritze, E.; Fritze, Jürgen

doi:10.1007/978-3-642-21081-5_1

Cited by 4 publications

(7 citation statements)

References 3 publications

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“…13 ) and in the closed form from Zea mays (PDB: 1SP8). 17 the sequence of the Arabidopsis thaliana HPPD in the X-ray crystallographic structure (Protein Data Bank (PDB): 5YWG). 13 Although HPPDs exist in dimers in eukaryotes, a ferrous ion is present in only one monomer of the dimer in plant HPPD, which has an active site (ligand binding site) and enzymatic function.…”

Section: Conformational Sampling and Free Energy Analysismentioning

confidence: 99%

“…C-terminal α-helix (H11) of HPPD exists in the closed and open forms, as illustrated in Figure 2. 17 In the closed form, H11 effectively shields the active center of the protein from substrates and inhibitors, preventing these molecules from binding to the protein active site. Conversely, in the open form, the protein exposes the active center toward the surrounding environment upon the structural change, thereby allowing substrates and inhibitors to bind to it.…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, in the open form, the protein exposes the active center toward the surrounding environment upon the structural change, thereby allowing substrates and inhibitors to bind to it. Therefore, H11 may act as a gate to the active center for substrates and inhibitors, 13,17 and the difference in the behavior of H11 may affect the resistance mutation of HPPD inhibitors. reported that H11 in Arabidopsis thaliana shifts between the open and closed forms during catalytic reactions with a preference for the open form, while Zea mays (a grass) prefers the closed form in the apo forms.…”

Section: Introductionmentioning

confidence: 99%

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Determination of the Association between Mesotrione Sensitivity and Conformational Change of 4-Hydroxyphenylpyruvate Dioxygenase via Free-Energy Analyses

Munei

Hengphasatporn

Hori

et al. 2023

J. Agric. Food Chem.

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One widely known herbicide target is 4-hydroxyphenylpyruvate dioxygenase (HPPD). Avena sativa HPPD is less sensitive to mesotrione (herbicide) than Arabidopsis thaliana HPPD. HPPD inhibitor-sensitivity is governed by the dynamic behavior of the C-terminal α-helix of HPPD (H11) in closed and open forms. However, the specific relationship between the plant inhibitor sensitivity and H11 dynamic behavior remains unclear. Herein, we determined the conformational changes in H11 to understand the inhibitor−sensitivity mechanism based on free-energy calculations using molecular dynamics simulations. The calculated free-energy landscapes revealed that Arabidopsis thaliana HPPD preferred the open form of H11 in the apo form and the closed-like form in complex with mesotrione, whereas Avena sativa HPPD exhibited the opposite tendency. We also identified some important residues involved in the dynamic behavior of H11. Therefore, inhibitor sensitivity is governed by indirect interactions due to the protein flexibility caused by the conformational changes of H11.

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Section: Conformational Sampling and Free Energy Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of the Association between Mesotrione Sensitivity and Conformational Change of 4-Hydroxyphenylpyruvate Dioxygenase via Free-Energy Analyses

Munei

Hengphasatporn

Hori

et al. 2023

J. Agric. Food Chem.

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“…Demzufolge ist es von spezieller Bedeutung und daher sehr von Vorteil, trotz einer gewissen Wiederholung im Text abgedruckter Passagen zu Risiken und Komplikationsmöglichkeiten die handschriftlichen Eintragungen in jedem Fall in angemessener Art und Weise vorzunehmen 3 , 6 , 8 , 12 , 13 , 16 . Dies gilt u. a. insbesondere für spezielle Risiken, die Aufklärung über Alternativverfahren und persönliche Empfehlungen.…”

Section: Begriffsbestimmung Rechtliche Grundlagenunclassified

Das ärztliche Aufklärungsgespräch vor invasiven Eingriffen

Weise¹

2022

Orthopädie und Unfallchirurgie up2date

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Sowohl die Aufklärung über als auch der Umgang mit unerwünschten Therapieergebnissen bedürfen in Zeiten ansteigender Zahlen von Behandlungsfehlerverfahren an Gerichten und den Schlichtungsstellen der Ärztekammern klarer Vorgaben bezüglich der Handlungsanleitung für Beschäftigte in medizinischen Einrichtungen. Die nachfolgenden Ausführungen sollen dazu beitragen, diesen eine Art strukturierte Handreichung für diesen wichtigen Aspekt der Interaktion zwischen Arzt und Patient aufzuzeigen.

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“…MdE-Tabellen. Im Bereich der Mund‑, Kiefer- und Gesichtschirurgie und der Zahnheilkunde muss allerdings in Ermangelung konsentierter Werte auf Vergleichswerte aus anderen Rechtsbereichen oder Fachgebieten zurückgegriffen werden [ 7 , 8 ].…”

Section: Gesetzliche Unfallversicherungunclassified