Alleviative effect of Ruellia tuberosa L. on NAFLD and hepatic lipid accumulation via modulating hepatic de novo lipogenesis in high‐fat diet plus streptozotocin‐induced diabetic rats

Abstract

Nonalcoholic fatty liver disease (NAFLD) has been associated with obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease (Browning et al., 2004). Defined as the presence of macrovesicular steatosis by more than 5% in liver of individuals without alcohol intake (Loomba & Sanya, 2013), NAFLD develops when the rate of fatty acid uptake and de novo lipogenesis (DNL) exceeds the rate of fatty acid output such as fatty acid oxidation and secretion of very-low-density lipoprotein (VLDL) (Fabbrini, Sullivan, & Klein, 2010). De novo lipogenesis is the main metabolic pathway for converting excess carbohydrate

Alpha‐lipoic acid alleviates NAFLD and triglyceride accumulation in liver via modulating hepatic NLRP3 inflammasome activation pathway in type 2 diabetic rats

“…NAFLD is defined as the presence of macrovesicular steatosis that TG level exceeding 5% in liver tissue of nondrinking individuals (Huang et al, 2020;Loomba & Sanya, 2013). The results of the present study indicate that NAFLD was induced in the HFD/STZ-treated rats.…”

“…Excessive calories or fat intake can cause lipid cells apoptosis, promote the activation of the inflammatory c‐Jun N‐terminal kinase 1 pathway, increase the secretion of cytokines, such as tumor necrosis factor (TNF)‐α or IL‐1β, and block insulin signaling in liver tissue, consequently resulting in compensatory insulin production by pancreatic β‐cells and the subsequent development of hyperinsulinemia (He et al., 2011). NAFLD is defined as the presence of macrovesicular steatosis that TG level exceeding 5% in liver tissue of nondrinking individuals (Huang et al., 2020; Loomba & Sanya, 2013). The results of the present study indicate that NAFLD was induced in the HFD/STZ‐treated rats.…”

Metabolomics and biochemical insights on the regulation of aging-related diabetes by a low-molecular-weight polysaccharide from green microalga Chlorella pyrenoidosa

“…1 d ). Epididymal fat weight significantly decreased following STZ administration ( Agunloye and Oboh, 2021 , Huang et al, 2020 ) ( p < 0.01). Weight of the epididymis fat in the normal group was significantly higher than that in the other four groups ( p < 0.01).…”

Betaine Alleviates High-Fat Diet-Induced Disruptionof Hepatic Lipid and Iron Homeostasis in Mice

“…The mechanisms underlying the excessive hepatic lipid deposition in NAFLD also differ in different animal models. Some studies reported enhanced uptake of circulating lipids and de novo lipogenesis [ 15 , 38 , 39 ], while others reported impaired fatty acid oxidation and TG export [ 40 , 41 , 42 ]. Numerous studies reported contribution of hepatic up-regulation of CD36 to NAFLD pathogenesis [ 13 , 14 , 15 ].…”