Alleviation of Porphyromonas gingivalis or Its Extracellular Vesicles Provoked Periodontitis and Cognitive Impairment by Lactobacillus pentosus NK357 and Bifidobacterium bifidum NK391

Ma, Xiaoyang; Yoo, Jong-Wook; Shin, Yoon-Jung; Park, Hee-Seo; Son, Young-Hoo; Kim, Dong-Hyun

doi:10.3390/nu15051068

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…Nonetheless, the genera Defluviitaleaceae_ UCG-011 and species Allobaculum sp., Lactobacillus mucosae, Lactobacillus rhamnosus, and Akkermansia muciniphila, which have been reported to have anti-inflammatory functions [54][55][56][57][58], were also found to be elevated in the YEH group. However, due to their relatively small proportion, their beneficial effects may not be evident in the overall outcome of the study.…”

Section: Discussionmentioning

confidence: 99%

The regulation of intestinal flora on host’s genes may play an essential role in the development of endometrial hyperplastic processes in yang deficiency individuals

Zhang

2024

Int J Clin Exp Pathol

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Yang-deficiency constitution (YADC) is linked to a higher vulnerability to various diseases, such as cold coagulation and blood stasis (CCBS) syndrome and infertility. Endometrial hyperplastic processes (EHPs) are a leading cause of infertility in women and are characterized by CCBS. However, it remains unclear whether YADC is related to the development of EHPs. Methods: We recruited 202 EHPs patients including 147 with YADC (YEH group) and 55 with non-YADC (NYEH group). Fecal samples were collected from 8 YEH patients and 3 NYEH patients and analyzed using 16S rRNA V3-V4 sequencing for gut microbiota analysis. We obtained constitution survey data and a differential gut microbiota dataset from the literature for further analysis. Bioinformatics analysis was conducted using gut microbiota-related genes from public databases. Results: YADC was significantly more prevalent in EHPs than non-YADC (P < 0.001), suggesting it as a potential risk factor for EHPs occurrence (OR population survey = 13.471; OR healthy women = 5.173). The YEH group had higher levels of inflammation, estrogen, and tamoxifen-related flora compared to NYEH and healthy YADC groups. There was an interaction between inflammation, estrogen, differential flora, and EHPs-related genes, particularly the TNF gene (related to inflammation) and the EGFR gene (related to estrogen), which may play a crucial role in EHPs development. Conclusion: YEH individuals exhibit significant changes in their gut microbiota compared to NYEH and healthy YADC. The interaction between specific microbiota and host genes is believed to play a critical role in the progression of EHPs.

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Section: Discussionmentioning

confidence: 99%

The regulation of intestinal flora on host’s genes may play an essential role in the development of endometrial hyperplastic processes in yang deficiency individuals

Zhang

2024

Int J Clin Exp Pathol

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“…Hippocampus, hypothalamus, and colon tissues were lysed in a RIPA lysis buffer and centrifuged, as previously reported [4]. Sera were prepared as previously reported [20]. BDNF, IL-1β, IL-2, IL-6, and tumor necrosis factor (TNF)-α levels were determined using commercial ELISA kits (R&D Systems, Minneapolis, MN, USA) [27].…”

Section: Eenzyme-linked Immunosorbent Assay (Elisa)mentioning

confidence: 99%

“…Lactobacillus rhamnosus HN001 improves DA in CUMS-treated mice and pregnancy [18,19]. Lactobacillus pentosus NK357 also mitigates gut inflammation (GI) and gut dysbiosis (GD) in pathogen-exposed mice [20].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus casei and Its Supplement Alleviate Stress-Induced Depression and Anxiety in Mice by the Regulation of BDNF Expression and NF-κB Activation

Shin

Park

et al. 2023

Nutrients

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Stress-induced depression and anxiety (DA) are closely connected to gastrointestinal inflammation and dysbiosis, which can suppress brain-derived neurotrophic factor (BDNF) in the brain. Herein, we isolated the BDNF expression-inducing probiotics Lactobacillus casei HY2782 and Bifidobacterium lactis HY8002 in lipopolysaccharide-stimulated SH-SY5Y cells. Then, we investigated the effects of HY2782, HY8002, anti-inflammatory L-theanine, and their supplement (PfS, probiotics-fermented L-theanine-containing supplement) on DA in mice exposed to restraint stress (RS) or the fecal microbiota of patients with inflammatory bowel disease and depression (FMd). Oral administration of HY2782, HY8002, or L-theanine alleviated RS-induced DA-like behaviors. They also decreased RS-induced hippocampal interleukin (IL)-1β and IL-6 levels, as well as NF-κB-positive cell numbers, blood corticosterone level, and colonic IL-1β and IL-6 levels and NF-κB-positive cell numbers. L-theanine more potently suppressed DA-like behaviors and inflammation-related marker levels than probiotics. However, these probiotics more potently increased RS-suppressed hippocampal BDNF level and BDNF+NeuN+ cell numbers than L-theanine. Furthermore, HY2782 and HY8002 suppressed RS-increased Proteobacteria and Verrucomicrobia populations in gut microbiota. In particular, they increased Lachnospiraceae and Lactobacillacease populations, which are closely positively associated with hippocampal BDNF expression, and suppressed Sutterellaceae, Helicobacteriaceae, Akkermansiaceae, and Enterobacteriaceae populations, which are closely positively associated with hippocampal IL-1β expression. HY2782 and HY8002 potently alleviated FMd-induced DA-like behaviors and increased FMd-suppressed BDNF, serotonin levels, and BDNF-positive neuronal cell numbers in the brain. They alleviated blood corticosterone level and colonic IL-1β α and IL-6 levels. However, L-theanine weakly, but not significantly, alleviated FMd-induced DA-like behaviors and gut inflammation. BDNF expression-inducing probiotic (HY2782, HY8002, Streptococcus thermophilus, and Lactobacillus acidophilus)-fermented and anti-inflammatory L-theanine-containing supplement PfS alleviated DA-like behaviors, inflammation-related biomarker levels, and gut dysbiosis more than probiotics or L-theanine. Based on these findings, a combination of BDNF expression-inducing probiotics with anti-inflammatory L-theanine may additively or synergistically alleviate DA and gut dysbiosis by regulating gut microbiota-mediated inflammation and BDNF expression, thereby being beneficial for DA.

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Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

Zhang,

Wu,

Liu

et al. 2024

Ageing Research Reviews

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Alleviation of Porphyromonas gingivalis or Its Extracellular Vesicles Provoked Periodontitis and Cognitive Impairment by Lactobacillus pentosus NK357 and Bifidobacterium bifidum NK391

Cited by 7 publications

References 37 publications

The regulation of intestinal flora on host’s genes may play an essential role in the development of endometrial hyperplastic processes in yang deficiency individuals

The regulation of intestinal flora on host’s genes may play an essential role in the development of endometrial hyperplastic processes in yang deficiency individuals

Lactobacillus casei and Its Supplement Alleviate Stress-Induced Depression and Anxiety in Mice by the Regulation of BDNF Expression and NF-κB Activation

Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

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