Alleviation of myoclonus after bilateral pallidal deep brain stimulation for Lance–Adams syndrome

Asahi, Takashi; Kashiwazaki, Daina; Dougu, Nobuhiro; Oyama, Genko; Takashima, Shutaro; Tanaka, Kortaro; Kuroda, Satoshi

doi:10.1007/s00415-015-7748-x

Cited by 21 publications

(24 citation statements)

References 15 publications

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“…In addition, piracetam has been recommended [16] . Because of the nonepileptic origin of the myoclonus, other therapeutic approaches addressed the idea of a movement disorder and suggested the use of l -5-hydroxytryptophan [17] , levodopa, and GABAergic drugs [18] including alcohol [19] , sodium oxybate [20] , baclofen [21] , or deep-brain stimulation [22] , [23] . The prognosis is bad; the efficacy of AEDs is usually limited.…”

Section: Discussionmentioning

confidence: 99%

Add-on perampanel in Lance–Adams syndrome

Steinhoff

Bacher

Kurth

et al. 2016

Epilepsy & Behavior Case Reports

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Perampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that has been licensed and marketed as antiepileptic drug (AED) indicated for patients with partial-onset and primary generalized tonic–clonic seizures. A positive effect was reported in some patients with epileptic myoclonic jerks in idiopathic generalized epilepsy and in progressive myoclonic epilepsy.We treated a male patient with posthypoxic nonepileptic myoclonus (Lance–Adams syndrome) with add-on PER and achieved an almost complete cessation of jerks. This effect was reproducible and, therefore, we suggest that it might be worth trying PER in comparable cases.

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Section: Discussionmentioning

confidence: 99%

Add-on perampanel in Lance–Adams syndrome

Steinhoff

Bacher

Kurth

et al. 2016

Epilepsy & Behavior Case Reports

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“…However, to the best of our knowledge, there have only been three reported cases of PHM treated with DBS (Table 1). Two of those cases were pallidal stimulation—one of which was unilateral to treat hemimyoclonus following a stroke,9 while the other was a bilateral implantation that effectively treated CPA-induced myoclonus in all extremities 11. Khobayashi et al10 reported a case of perinatal anoxia-induced action myoclonus successfully treated with bilateral VIM-DBS.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, patients with PHM usually require a combination of the classes of aforementioned medications with variable responses. Deep brain stimulation (DBS) has been suggested in patients with chronic PHM, but there have been only three reported cases of PHM treated with DBS 9–11. We report a fourth case of a patient with PHM following an asthmatic attack and CPA who was effectively treated with DBS, and only the second case to utilize bilateral globus pallidus internus (GPi) stimulation.…”

Section: Introductionmentioning

confidence: 95%

Improvement of Post-hypoxic Myoclonus with Bilateral Pallidal Deep Brain Stimulation: A Case Report and Review of the Literature

Ramdhani

Kopell²

2017

Tremor and Other Hyperkinetic Movements

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“…In a case of perinatal hypoxia, the target of stimulation was the thalamus but in the other two cases the stimulation target was the globus pallidus internus. 51 , 52 , 53 Further work on deep brain stimulation surgery will hopefully confirm effectiveness and clarify the preferred site of stimulation. Intrathecal baclofen therapy has also been shown to improve myoclonus in a patient refractory to multiple medications.…”

Section: Methodsmentioning

confidence: 97%