Alleviation of diazepam-induced conditioned place preference and its withdrawal-associated neurobehavioral deficits following pre-exposure to enriched environment in rats

Haider, Saida; Nawaz, Amber; Batool, Zehra; Tabassum, Saiqa; Perveen, Tahira

doi:10.1016/j.physbeh.2019.112564

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Accordingly, it is used as a pharmacological model to induce depression-like behavior in rodents. 3 Radiation exposure has multiple effects which depend mainly on the dose received. High radiation doses can induce severe tissue damage, while lower doses can activate natural protection by stimulating the immune system and numerous cell regulatory proteins.…”

Section: Introductionmentioning

confidence: 99%

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Karam

Radwan

2020

Environmental Toxicology

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The low dose of radiation (LDR) has received growing attention for its beneficial neuroprotective effect. This study was designed to investigate the enhancing effect of LDR on the antidepressant potential of resveratrol against diazepam‐induced depression in mice. Female mice divided into five groups; control, diazepam (2 mg/kg), LDR (0.5Gy) + diazepam, resveratrol (20 mg/kg) + diazepam, LDR + resveratrol+diazepam. Mice received diazepam showed depressive symptoms as evidenced by decreased locomotor activity in the open field and increased immobility time in the forced swimming and tail suspension tests integrated with a marked decline in biogenic amines (serotonin, norepinephrine, and dopamine) in brain tissues. These effects were ameliorated by LDR or resveratrol administration demonstrating an antidepressant activity. Interestingly, LDR triggered the antidepressant effect of resveratrol as it restored the changes in behavioral tests, neurotransmitters, and neuro‐histoarchitecture. In conclusion, these findings suggested that LDR could be considered as a novel adjuvant that augmented the resveratrol antidepressant effect and might serve as a potential therapeutic approach for depression.

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Section: Introductionmentioning

confidence: 99%

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Karam

Radwan

2020

Environmental Toxicology

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“…The aforementioned results supported the intervention effects of OE on intestinal microorganisms in SD rats. Additionally, in all experiments, OE exhibited similar intervention effects to diazepam tablets (positive control), one of the widely prescribed sedative drugs for the treatment of anxiety and sleep disorders [ 94 , 95 ].…”

Section: Discussionmentioning

confidence: 99%

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Cao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Okra, possessing various bioactive components, is used to treat different diseases. This study sought to estimate the intervention effects of okra extract (OE) on brain-gut peptides (BGPs) and intestinal microorganisms in sleep deprivation (SD) rats. Methods. SD rat models were established using the modified multiple platform method and then treated with normal saline, diazepam tablets, or different doses of OE. Body weight and average daily water consumption of rats were recorded. Depressive behaviors of rats were assessed by the open field test and sucrose preference test. Serum levels of noradrenaline, melatonin, inflammatory factors (IL-1β/IL-6/TNF-α/IL-4/IL-10), and BGP indexes, including gastrin (GAS), motilin (MTL), 5-hydroxytryptamine (5-HT), cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were measured by ELISA. Additionally, the DNA relative contents of representative intestinal microorganisms in the collected rat feces were determined using RT-qPCR. Results. SD decreased body weight and average daily water consumption and induced depressive behaviors as well as stress and inflammatory responses in rats. SD rats exhibited lowered GAS, MTL, 5-HT, and VIP but elevated CCK and showed diminished DNA relative contents of Bacteroidetes and probiotics (Bifidobacteria and Lactobacilli) but increased Clostridium perfringens. OE at different doses ameliorated the depressive behaviors and mitigated the stress and inflammatory responses in SD rats, raised the serum contents of GAS, MTL, 5-HT, and VIP, reduced CCK level, elevated the DNA relative contents of Bacteroidetes and probiotics, but diminished Clostridium perfringens. OE exhibited similar intervention effects to diazepam tablets (positive control). Conclusion. OE exerts intervention effects on BGPs and intestinal microorganisms in SD rats.

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“…The OFT was used to evaluate locomotor activity and anxiety-like behavior ( Haider et al, 2019 ; Kaur et al, 2019 ; Yunusoğlu, 2021 ; Miao et al, 2023 ). Before testing, rats were put into the experimental environment for 30 min to acclimate to it.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study

Han,

Jing,

Han

et al. 2023

Front. Neurosci.

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Since their introduction in the United States and Europe in 2007, electronic cigarettes (E-Cigs) have become increasingly popular among smokers. Nicotine, a key component in both tobacco and e-cigarettes, can exist in two forms: nicotine-freebase (FBN) and nicotine salts (NS). While nicotine salt is becoming more popular in e-cigarettes, the effect of nicotine salts on reinforcement-related behaviors remains poorly understood. This study aimed to compare the reinforcing effects of nicotine and nicotine salts in animal models of drug self-administration and explore potential mechanisms that may contribute to these differences. The results demonstrated that three nicotine salts (nicotine benzoate, nicotine lactate, and nicotine tartrate) resulted in greater reinforcement-related behaviors in rats compared to nicotine-freebase. Moreover, withdrawal-induced anxiety symptoms were lower in the three nicotine salt groups than in the nicotine-freebase group. The study suggested that differences in the pharmacokinetics of nicotine-freebase and nicotine salts in vivo may explain the observed behavioral differences. Overall, this study provides valuable insights into the reinforcing effects of nicotine as well as potential differences between nicotine-freebase and nicotine salts.

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Alleviation of diazepam-induced conditioned place preference and its withdrawal-associated neurobehavioral deficits following pre-exposure to enriched environment in rats

Cited by 9 publications

References 33 publications

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Low dose γ radiation enhances antidepressant effect of resveratrol: Behavioral and neurochemical studies

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study

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