Alleviation effects of<i>Rubus coreanus</i>Miquel root extract on skin symptoms and inflammation in chronic atopic dermatitis

Kim, Jong-Hwa; Kim, Wonyong

doi:10.1039/d1fo03580k

Cited by 5 publications

(5 citation statements)

References 45 publications

(42 reference statements)

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“…EA was also considered the main bioactive compounds in Rubus coreanus Miquel root extract (100 mg/kg, topically), which was shown to control the severity of diseases in a DNCB-induced NC/Nga mouse model. The extract had comparable effect to tacrolimus ointment, used as positive control at the same concentration (100 mg/kg, topically) [ 89 ]. The summary of commented articles is reported in Table 4 .…”

Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

et al. 2022

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Plants rich in hydrolyzable tannins were traditionally used all over the world for a variety of chronic inflammatory disorders, including arthritis, colitis, and dermatitis. However, the knowledge of their immunological targets is still limited though fundamental for their rational use in phytotherapy. The recent advances regarding the pathogenesis of inflammatory-based diseases represent an opportunity to elucidate the pharmacological mechanism of plant-derived metabolites with immunomodulatory activity. This review collects recent articles regarding the role of hydrolyzable tannins and their gut metabolites in Th1, Th2, and Th17 inflammatory responses. In line with the traditional use, rheumatoid arthritis (RA), inflammatory bowel diseases (IBDs), psoriasis, atopic dermatitis (AD), and asthma were the most investigated diseases. A substantial body of in vivo studies suggests that, beside innate response, hydrolyzable tannins may reduce the levels of Th-derived cytokines, including IFN-γ, IL-17, and IL-4, following oral administration. The mode of action is multitarget and may involve the impairment of inflammatory transcription factors (NF-κB, NFAT, STAT), enzymes (MAPKs, COX-2, iNOS), and ion channels. However, their potential impact on pathways with renewed interest for inflammation, such as JAK/STAT, or the modulation of the gut microbiota demands dedicate studies.

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Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

et al. 2022

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“…Inhibitory effects on release and activity from HMC-1 cells were performed as previously described [ 15 ]. Briefly, to the β-hexosaminidase inhibition assays, HMC-1 cells were seeded at 2 × 10 6 cells/well and added Tyrode’s buffer (0.4 mM NaH 2 PO 4 , 1.8 mM CaCl 2 , 2.7 mM KCl, 5.6 mM glucose, 11.9 mM NaHCO 3 , and 137 mM NaCl; pH 7.2) and L. lactis LB 1022 (10 8 CFU/ml) for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Potential Anti-Allergy and Immunomodulatory Properties of Lactococcus lactis LB 1022 Observed In Vitro and in an Atopic Dermatitis Mouse Model

Baek

Kim

2023

J. Microbiol. Biotechnol.

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Lactococcus lactis is a lactic acid bacterium and used in the dairy food industry. The ameliorating effects of Lactobacillus species on atopic dermatitis (AD) have been extensively studied, but the specific effect of L. lactis strains has not yet been investigated. In this study, the efficacy of L. lactis LB 1022, isolated from natural cheese, was evaluated using RAW 264.7, HMC-1 and HaCaT cell lines and an ovalbumin-sensitized AD mouse model. L. lactis LB 1022 exhibited nitric oxide suppression and anti-allergy and anti-inflammatory activity in vitro. Oral administration of L. lactis LB 1022 to AD mice significantly reduced the levels of IgE, mast cells, and eosinophils, and a range of T cell-mediated T helper Th1, Th2, and Th17-type cytokines under interleukin (IL)-10, transforming growth factor-β (TGF-β), thymus and activation-regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP). In addition, L. lactis LB 1022 treatment increased the concentration of short-chain fatty acids. Overall, L. lactis LB 1022 significantly modulated AD-like symptoms by altering metabolites and the immune response, illustrating its potential as candidate for use in functional food supplements to alleviate AD.

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“…Therefore, we investigated ISO’s effect and explored its potential underlying molecular mechanisms in AD. A benzene derivative, 1-chloro-2,4-dinitrochlorobenzene (DNCB), which is highly electrophilic and cytotoxic, can induce clinical conditions similar to AD in mice ( 38 , 39 ). The aim of this study was to test the inhibitory effects of ISO on AD in NC/Nga mice induced by DNCB, and at the same time, test its effects in the human mast cell line HMC1.1 treated by calcium ionophore A23187/phorbol-12-myristate-13-acetate (PMA).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of isoliquiritin on an atopic dermatitis model through the CD177/JAK2/STAT pathway in vitro and in vivo

Wu¹,

Mo²,

Lin³

et al. 2022

Ann Transl Med

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Background: Atopic dermatitis (AD) is a complex inflammatory skin condition characterized by the proliferation and activation of immune cells in skin. Isoliquiritin (ISO) is an active component purified from Glycyrrhiza glabra. This study aimed to test the therapeutic potential of ISO for AD and verify its potential molecular mechanism.Methods: This study investigated the potential effects and possible underlying mechanisms of ISO against AD in vitro (HMC1.1 cells stimulated by phorbol-12-myristate-13-acetate and calcium ionophore A23187) and in vivo (AD-like mouse model induced by 1-chloro-2,4-dinitrochlorobenzene).Results: ISO dose-dependently suppressed the viability of HMC1.1 cells. ISO inhibited the secretion of the proinflammatory factors IL-6 and IL-8 and induced the apoptosis of HMC1.1 cells. ISO suppressed the phosphorylation of CD177, JAK2, STAT1, STAT3, and STAT5, and upregulated the protein expression of BAX and cleaved caspase-3 in vitro. ISO administration markedly diminished the infiltration of immune cells (mast cells, eosinophils) in cutaneous lesions. Simultaneously, ISO treatment alleviated the formation of skin lesions and affected other AD symptoms (thickness of the epidermis and dermis, ear edema, lymph node weight, spleen index, dermatitis score) but increased the thymus index in vivo, and downregulated expression of IL-4, IL-6, IgE, and thymic stromal lymphopoietin (TSLP).Conclusions: Collectively, our findings showed that ISO administration decreased skin lesion formation by inhibiting inflammation and enhancing immunomodulation through the CD177/JAK2/STAT signaling pathway.

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Alleviation effects ofRubus coreanusMiquel root extract on skin symptoms and inflammation in chronic atopic dermatitis

Abstract: Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic inflammatory dermatitis with immunological manifestations. The aim of this study was to investigate the effects of polyphenol-containing Rubus coreanus...

Cited by 5 publications

References 45 publications

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

Potential Anti-Allergy and Immunomodulatory Properties of Lactococcus lactis LB 1022 Observed In Vitro and in an Atopic Dermatitis Mouse Model

Inhibitory effects of isoliquiritin on an atopic dermatitis model through the CD177/JAK2/STAT pathway in vitro and in vivo

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