Alleviating psoriatic skin inflammation through augmentation of Treg cells via CTLA-4 signaling peptide
Woo-Sung Lee,
Kyung-Ho Nam,
Jong Hoon Kim
et al.
Abstract:Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of keratinocytes and immune cell infiltration. The IL-17-producing T cells play a key role in psoriasis pathogenesis, while regulatory T (Treg) cells are diminished during psoriatic inflammation. Current psoriasis treatments largely focus on IL-17 and IL-23, however, few studies have explored therapeutic drugs targeting an increase of Treg cells to control immune homeostasis. In this study, we investigated the effects of a cytotoxic … Show more
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