Allergy to several local anesthetics from the amide group

Domínguez‐Ortega, Javier; Phillips-Anglés, Elsa; González‐Muñoz, Miguel; Heredia, R Maese; Fiandor, Ana; Quirce, Santiago

doi:10.1016/j.jaip.2016.02.009

Cited by 9 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our present data include relatively superficial eczematous reactions resembling allergic contact dermatitis, and deep, cellulitis‐like tissue inflammation. These observations are in accordance with case reports covering the same range from superficial eczematous to deep cellulitis‐like reactions . The term “deep impact contact allergy” has been proposed to refer to the latter .…”

Section: Discussionsupporting

confidence: 90%

“…These observations are in accordance with case reports covering the same range from superficial eczematous to deep cellulitis-like reactions. 7,8,[30][31][32][33][34][35] The term "deep impact contact allergy" has been proposed to refer to the latter. 8 In a previous case report, we reported that LAs may be clinically tolerated despite sensitization if they are deliberately injected into the deep subcutaneous tissue.…”

Section: Localized Allergy Casesmentioning

confidence: 99%

See 1 more Smart Citation

Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity

Trautmann

Stoevesandt

2018

Contact Dermatitis

View full text Add to dashboard Cite

Background: Anaphylaxis-like reactions developing within a few minutes are the most frequent complications of subcutaneous or submucosal injections of local anaesthetics (LAs), and topically applied LAs are potential contact allergens. In addition, injected LAs have been reported to induce delayed reactions, including local inflammation at the injection site, and various general symptoms.Objectives: To assess the frequency and symptoms of late-type hypersensitivity occurring several hours after LA injections.Methods: We retrospectively evaluated clinical data and test results from all patients referred to our allergy clinic in a period of 20 years for diagnostic work-up of LA-associated late-type reactions.Results: Of 202 patients reporting symptoms with onset at least 1 hour after LA injection, 40 had cutaneous inflammation confined to the injection site, and 162 reported various systemic symptoms. LA hypersensitivity could be excluded in all patients with systemic complaints by means of skin testing and subsequent subcutaneous provocation. In 8 of the 40 patients (20%) with local inflammatory reactions, late-type allergic LA hypersensitivity was confirmed.Conclusions: Late-type LA allergy commonly causes inflammatory skin reactions confined to the injection site. Conversely, LAs are highly unlikely to trigger delayed systemic symptoms such as urticarial or exanthematous skin eruptions.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Localized Allergy Casesmentioning

confidence: 99%

Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity

Trautmann

Stoevesandt

2018

Contact Dermatitis

View full text Add to dashboard Cite

show abstract

“… 9 , 14 , 18 Immediate LA-hypersensitivity reactions (HR), though rare, have also been reported as a cause of anaphylaxis. 16 , 19–22 Moreover, patients necessitating evaluation for anaphylaxis-like symptoms after the use of LA are disproportionately common. 18 …”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Immediate-Type Local Anesthetic Hypersensitivity Reactions in Pediatric Patients: A Retrospective Case-Control Study

Süleyman

Tamay

Güler

2022

JAA

View full text Add to dashboard Cite

Background Local anesthetics (LA) are relatively safe and rarely cause immediate hypersensitivity reactions. The data on immediate LA hypersensitivity and its risk factors in children are limited. Aim To evaluate risk factors of immediate LA hypersensitivity. Methods The retrospective case-controlled study included 17 patients with confirmed immediate LA hypersensitivity. For each patient, three age- and gender-matched control subjects were included in the study. LA hypersensitivity was excluded by skin tests and subcutaneous drug provocation tests in all control subjects. Results The most common allergic assessment in the patient/control group was for lidocaine (n=5; 29.4%, vs n=23; 45.1%). Suspected LA hypersensitivity reactions were found to be associated with cutaneous manifestations in 14 (82.4%) patients and in 7 (13.7%) of the controls. A history of exposure to local anesthetics twice or more was present in 11 (64.7%) patients vs 6 (11.8%) controls. In conditional regression analysis, repeated LA exposure (≥2) and cutaneous findings were determined as significant risk factors (Odds Ratio [OR]:5.7; 95% Confidence Interval [CI]:1.2–27.1; P=0.029 and (OR:17.3; 95% CI:3.6–82.5; P<0.001, respectively). Conclusion Cutaneous manifestations and a history of LA exposure twice or more were predictive factors for LA allergy confirmed by skin test in children.

show abstract

Developing an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis

Enokiya,

Ozaki

2024

DARU J Pharm Sci

View full text Add to dashboard Cite

Allergy to several local anesthetics from the amide group

Cited by 9 publications

References 6 publications

Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity

Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity

Risk Factors for Immediate-Type Local Anesthetic Hypersensitivity Reactions in Pediatric Patients: A Retrospective Case-Control Study

Developing an AI-based prediction model for anaphylactic shock from injection drugs using Japanese real-world data and chemical structure-based analysis

Contact Info

Product

Resources

About