Allergy to propofol?

Jamieson, Virginia; Mackenzie, J. W.

doi:10.1111/j.1365-2044.1988.tb05454.x

Cited by 12 publications

(3 citation statements)

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“…PI would appear to bear three chains, TK three chains and I3 eight chains, numbers which do not exceed the potential N-glycosylation sites on the primary sequence of the relevant proteins (Misumi et al, 1990;Schreiber, 1987;Braciak et a]., 1988). Our results would be consistent with previous reports that transferrin secretion is not modified by inhibitors of N-glycosylation (Bauer et al, 1985 a;Lodish and Kong, 1984), whereas that of AGP (Andus et al, 1983;Jamieson, 1988) and PI (Bauer et al, 1985a;Lodish and Kong, 1984) is impaired. Analogous conclusions have been drawn with regard to endocytosis: the degree of uptake of asialotransferrin mediated by the hepatocyte plasma membrane Gal/GalNAc lectin is considerably lower than that of other asialoglycoproteins (Morel1 et al, 1971).…”

Section: Discussionmentioning

confidence: 72%

Differential rates of glycoprotein secretion by isolated rat hepatocytes studied in terms of concanavalin A binding

Poüs

Drechou

Rouzeau

et al. 1992

European Journal of Biochemistry

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Using a concanavalin-A-based method which respects cell function, we have shown that the kinetics of glycoprotein secretion appear to depend on the nature of the oligosaccharide moiety. In 37 "C pulse/chase experiments using freshly isolated normal rat hepatocytes, we found that except for transferrin, whose rate of secretion was independent of its concanavalin A reactivity, the secretion of the concanavalin-A-retained forms of a1 acid glycoprotein, T-kininogen, a1 protease inhibitor and a1 inhibitor 111 was slower than that of the concanavalin-A-non-retained forms. When hepatocytes were incubated at 20 "C, secretion was blocked with the accumulation of mainly endoglycosidase-Hsensitive forms. The secretion kinetics of the concanavalin-A-differentiated forms were still different when the temperature was shifted back to 37°C. The divergence between the secretion rates of the concanavalin-A-differentiated forms would appear to be due to a late event in intracellular protein trafficking, which may depend on the sugar content and/or the number of carbohydrate chains of the glycoproteins.Although the roles of the N-linked oligosaccharides present on glycoproteins are not yet fully understood, they can influence the behaviour of these molecules. From a physical point of view, oligosaccharides confer correct folding, conformational stability and protease resistance (Chow et al., 1984; Machamer and Rose, 1988). With regard to biological functions, oligosaccharides are also strongly involved in recognition processes such as cell/cell interaction and intracellular protein targeting (Olden et al

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Section: Discussionmentioning

confidence: 72%

Differential rates of glycoprotein secretion by isolated rat hepatocytes studied in terms of concanavalin A binding

Poüs

Drechou

Rouzeau

et al. 1992

European Journal of Biochemistry

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show abstract

“…Typically, propofol is cited in literature to possess bronchodilating properties thereby decreasing wheezing and reducing exacerbations of asthma in the asthmatic individual [1,3]. However, bronchospastic episodes and other reactions following propofol administration have been documented [1,[4][5][6][7][8][9][10][11][12][13][14]. Previously proposed etiologies for propofol reactions include a phenomenon related to histamine release as well as a reactionary cascade secondary to various chemical compounds found in propofol [5][6][7].…”

Section: Discussionmentioning

confidence: 98%

“…Both the preservative and the formulation have been known to exacerbate asthmatic conditions with cases documented in literature [1,3,9]. Sodium metabisulfite or rather the sulfite by-product [15] can induce rash, anaphylaxis, anaphylactoid reaction, eczema, and even death with approximately 10% of asthmatic patients believed to be sulfite sensitive [4,12,13,16]. Bronchospasm, laryngospasm, and wheezing occurred in less than 1% of the clinical trial population of 2889 patients receiving general or MAC sedation [1].…”

Section: Discussionmentioning

confidence: 99%