Allergy to human seminal fluid: Cross-reactivity with dog dander

Basagaña, María; Bartolomé, B; Pastor, Carlos; Torres, Ferrán; Alonso, Ricardo; Vivanco, Fernando; Cisteró-Bahíma, A

doi:10.1016/j.jaci.2007.10.008

Cited by 57 publications

(42 citation statements)

References 29 publications

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“…Here we present the case of a 38-year-old nulligravida woman who experienced anaphylactic reactions after sexual intercourse since her first coitus, as previously described by our group [2,9]. The patient was monosensitized to dog dander since she was 18 years old, and she suffers from bronchial asthma due to this sensitization.…”

Section: Methodsmentioning

confidence: 72%

“…In two separate studies of HSPA, prostate-specific antigen (PSA) hasbeenidentified as the causative allergen [2,3]. In one of these studies, cross-reactivity between human PSA and dog dander proteins was demonstrated [2].…”

Section: Introductionmentioning

confidence: 99%

“…In one of these studies, cross-reactivity between human PSA and dog dander proteins was demonstrated [2]. …”

Section: Introductionmentioning

confidence: 99%

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Involvement of Can f 5 in a Case of Human Seminal Plasma Allergy

Basagaña

Bartolomé²,

Pastor-Vargas³

et al. 2012

Int Arch Allergy Immunol

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Background: The existence of IgE binding to dog dander extract without IgE antibodies against the described dog allergens (Can f 1, 2, 3 and 4) implies the presence of other dog allergens yet to be identified. Recently, an IgE-binding protein was isolated from dog urine and identified as prostatic kallikrein; it has been named Can f 5. Cross-reactivity between a dog dander allergen and human prostate-specific antigen (PSA) has been described. The aim of this study was to identify the dog dander allergen that presents cross-reactivity with PSA and demonstrate its clinical relevance in our patient with human seminal plasma allergy. Methods: SDS-PAGE immunoblotting and inhibition tests were performed. Mass spectrometry was carried out to identify the protein involved in the allergy reactions. Results: SDS-PAGE immunoblotting-inhibition with an IgE-binding protein from dog prostatic secretion showed total IgE binding inhibition to a 28-kDa IgE-reactive band identified as PSA. The electroeluted protein from dog prostatic secretion was identified by mass spectrometry as Can f 5. IgE immunoblotting of human seminal plasma incubated with the serum of the patient revealed two IgE-binding bands (28 and 32.7 kDa). Both SDS-PAGE immunoblotting inhibition assays, with human seminal plasma or purified PSA in solid phase, showed complete IgE binding inhibition when the serum of the anaphylactic patient was preincubated with dog dander extract or recombinant Can f 5. Conclusions: The dog dander allergen that shows cross-reactivity with human PSA has been characterized and turns out to be the recently described Can f 5. We demonstrated the clinical relevance of this cross-reactivity in a patient.

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Section: Methodsmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Involvement of Can f 5 in a Case of Human Seminal Plasma Allergy

Basagaña

Bartolomé²,

Pastor-Vargas³

et al. 2012

Int Arch Allergy Immunol

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“…54 Other causes of anaphylaxis are related to drugs such as: antibiotics (particularly beta-lactams ones), analgesics and anti-inflammatory medications, anesthesia medications and even apparently harmless substances such as folic acid and vitamins. 55 Other examples of drugs causing severe reactions of hypersensitivity are monoclonal antibodies (cetuximab, infliximab and omalizumab); [56][57][58] immunotherapy and allergy skin tests, [59][60] infectious diseases prevention vaccines, or their excipients such as gelatin, dextran and egg traces, 61 radiological contrast media, 62 latex, 63 cold, 64 physical exercise, 65 seminal fluid 66 and many less common agents such as: glue, seeds, mold and cleaning products 17,37 . Finally, it has been recently described a new trigger of anaphylaxis occurring in patients with specific IgE antibody to galactose-α1,3-galactose (α-Gal), a carbohydrate present in non-primate mammalian proteins.…”

Section: -Twomentioning

confidence: 99%

Epidemiology of anaphylaxis

Silva¹,

Castro²

2014

Brazilian Journal of Allergy and Immunology (BJAI)

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Anaphylaxis is a hypersensitivity disease whose main features are the severity, the acute presentation and the possible progression to shock and / or respiratory failure unless the patient is immediately treated. Its prevalence is not fully known, varying according to the surveyed areas around the world, and for reasons not fully understood, its frequency and severity are increasing. Through epidemiological studies, it is possible to better investigate the disease, its triggers and associated co-factors, and its prevention. This review addresses the major epidemiological studies conducted on the topic in recent decades.

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“…8 Moreover, few dog dander allergens demonstrate cross-reactivity with an allergic protein in human seminal plasma. 9,10 Furthermore, it has been hypothesized that an infection by microorganisms that introduce cross-reacting antigens may also result in the production of anti-sperm antibodies. 11 Levine et al have revealed that the causative antigen, which is a small protein, seems ubiquitous in the human prostatic secretion.…”

Section: Introductionmentioning

confidence: 99%

Seminal Plasma Allergy : A Literature Review

Nishihara

Shimizu²,

Ichihara

et al. 2015

J of Gen and Family Med

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Seminal plasma allergy (SPA) is an immunological reaction against human seminal plasma observed in women. SPA is not a well-known clinical syndrome, considering that there are few epidemiological studies on SPA, and it can often be overlooked or misdiagnosed as other medical conditions. Symptoms occur after sexual intercourse and manifest as systemic and/or localized symptoms. The pathophysiology of SPA is commonly assumed to be autoimmune reaction to seminal plasma with IgE antibodies ; however, it is still uncertain which specific antibodies cause SPA. In vivo skin tests, including prick and intradermal tests, are useful for diagnosing SPA. However, there has been no consensus on treatment of SPA, apart from symptomatic therapy, although several desensitization methods have been reported, using emergency kits for allergic reactions. The most common and most effective preventive measure for SPA is to use condoms during intercourse.

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Allergy to human seminal fluid: Cross-reactivity with dog dander

Cited by 57 publications

References 29 publications

Involvement of Can f 5 in a Case of Human Seminal Plasma Allergy

Involvement of Can f 5 in a Case of Human Seminal Plasma Allergy

Epidemiology of anaphylaxis

Seminal Plasma Allergy : A Literature Review

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