Allergy to beta-lactams in pediatrics: a practical approach

Grumach, Anete Sevciovic

doi:10.2223/jped.1558

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…If prescription of a β‐lactam is necessary, a practical approach to the diagnosis of allergy requires a careful clinical history, SPT and intradermal testing. Children with negative tests should undergo oral challenge to identify the false negatives from skin testing and this is particularly important for accelerated and delayed reactions which are unlikely to be IgE‐mediated [27, 132]. Children in whom the diagnosis of β‐lactam allergy has been excluded previously by skin testing and/or oral challenge, have a low prevalence of subsequent adverse reactions to β‐lactams and subsequent skin testing for β‐lactams is unnecessary [133].…”

Section: Drug Allergy In Childrenmentioning

confidence: 99%

BSACI guidelines for the management of drug allergy

Mirakian

Ewan

Durham

et al. 2009

Clin Experimental Allergy

208

199

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SummaryThese guidelines have been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) and are intended for allergists and others with a special interest in allergy. As routine or validated tests are not available for the majority of drugs, considerable experience is required for the investigation of allergic drug reactions and to undertake specific drug challenge. A missed or incorrect diagnosis of drug allergy can have serious consequences. Therefore, investigation and management of drug allergy is best carried out in specialist centres with large patient numbers and adequate competence and resources to manage complex cases. The recommendations are evidencebased but where evidence was lacking consensus was reached by the panel of specialists on the committee. The document encompasses epidemiology, risk factors, clinical patterns of drug allergy, diagnosis and treatment procedures. In order to achieve a correct diagnosis we have placed particular emphasis on obtaining an accurate clinical history and on the physical examination, as these are critical to the choice of skin tests and subsequent drug provocation. After the diagnosis of drug allergy has been established, communication of results and patient education are vital components of overall patient management.

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Section: Drug Allergy In Childrenmentioning

confidence: 99%

BSACI guidelines for the management of drug allergy

Mirakian

Ewan

Durham

et al. 2009

Clin Experimental Allergy

208

199

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“…The results of a study by Nelson A. et al allowed the conclusion that the incorrect diagnosis of penicillin allergy frequently leads to the exclusion of this drug as a therapeutic option. A better recognition of these situations will enable the use of penicillin and reduce the risks associated with hypersensitivity [18].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk

et al. 2021

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Adverse drug reactions (ADRs) are unexpected reactions to a medication administered in a correct way at a standard dose. Drug-induced skin reactions account for 60–70% of all ADRs. The aim of the study is to determine the prevalence of antibiotic-related dermatological ADR in patients treated in the department of Dermatology, Venerology and Allergology of the University Clinical Center in Gdańsk, Poland, in the years 2004–2021. A retrospective analysis of patients’ medical files was conducted in order to identify cases of ADR connected with the use of antibiotics, yielding 84 cases. The most common group of antibiotics were β-lactam, causing ADR in 47 patients. β-lactam antibiotics in our study included amoxicillin, alone and combined with clavulanic acid, and cephalosporins, affecting 22, 18 and 7 patients, respectively. In conclusion, β-lactam antibiotics showed the highest prevalence among antibiotic-induced skin reactions. They accounted for 15% of cases of all dermatological drug reactions and 55% of those caused by antibiotics. Especially amoxicillin, prescribed as a single drug or in combination with clavulanic acid, was commonly the culprit. Due to its wide use in the hospital and outpatient clinic, these adverse reactions have to be kept in mind by both hospital staff and general practitioners.

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“…El prick test tendría una especificidad de 65-73% y sensibilidad de 95,2%. Estos indicadores se obtuvieron mediante el uso de peniciloil, penicilenato y penaldato, penicilina sódica y amoxicilina (15)(16)(17) .…”

Section: Pruebas Diagnósticasunclassified

Alergia a ß-lactámicos en niños

2019

Rev. Hosp. Clín. Univ. Chile (En línea)

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Allergy to Betalactams is a widely suspected pathology, which is not regularly studied in Chile, leading to a misusage of antibiotics of other families. In this article a case report in a pediatric patient will be described, and a discussion about the studies needed for this pathology, and treatment will be made in accordance to the experiences and tools available in Chile, and specifically in University of Chile Clinical Hospital. In our Hospital we study these cases following international guidelines for the diagnosis of allergy to Betalactams.

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Allergy to beta-lactams in pediatrics: a practical approach

Cited by 12 publications

References 38 publications

BSACI guidelines for the management of drug allergy

BSACI guidelines for the management of drug allergy

Antibiotic-Related Adverse Drug Reactions in Patients Treated on the Dermatology Ward of Medical University of Gdańsk

Alergia a ß-lactámicos en niños

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