Allergy Testing in Childhood: Using Allergen-Specific IgE Tests

Sicherer, Scott H.; Wood, Robert A.; Abramson, Stuart L.; Chipps, Bradley E.; Fleisher, Thomas A.; Lester, Mitchell R.; Mahr, Todd A.; Matsui, Elizabeth C.; Virant, Frank S.; Williams, Paul V.

doi:10.1542/peds.2011-2382

Cited by 125 publications

(92 citation statements)

References 19 publications

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“…Despite these systems provided the result in the same unit, the result is not always equivalent. 3,[8][9][10] Euroline (Euroimmun, Medizinische Labordiagnostika, AG, Germany), an IgE determination system using immunoblotting assay has some advantages such as the requirement of only small amount of sera, no automate machine requirement, minimal hands-on time, appropriate for screening multiple allergen and cost-saving. While ImmunoCAP (Phadia, Uppsala, Sweden), a fluorescence/enzyme-immunoassay, has some advantages such as high through-put with a lot of number of sample load per day but it has some disadvantage such as automate machine requirement and expensive.…”

Section: Performance Of Immunoblotting Assay (Euroline) and Fluorescementioning

confidence: 99%

Comparison of specific IgE detection by immunoblotting and fluorescence enzyme assay with in vivo skin prick test

Wongpiyabovorn

Suratannon

Boonmee

et al. 2017

Asian Pac J Allergy Immunol

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Section: Performance Of Immunoblotting Assay (Euroline) and Fluorescementioning

confidence: 99%

Comparison of specific IgE detection by immunoblotting and fluorescence enzyme assay with in vivo skin prick test

Wongpiyabovorn

Suratannon

Boonmee

et al. 2017

Asian Pac J Allergy Immunol

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“…86 Food allergy Children can have positive immunoglobulin E test results indicating sensitization but not necessarily suffer from a clinical allergy. 87 For example, 17% of people are sensitized to a major food allergen, but only 2.5% have a clinical food allergy. 88 …”

Section: Bacteremiamentioning

confidence: 99%

Overdiagnosis: How Our Compulsion for Diagnosis May Be Harming Children

et al. 2014

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Overdiagnosis occurs when a true abnormality is discovered, but detection of that abnormality does not benefit the patient. It should be distinguished from misdiagnosis, in which the diagnosis is inaccurate, and it is not synonymous with overtreatment or overuse, in which excess medication or procedures are provided to patients for both correct and incorrect diagnoses. Overdiagnosis for adult conditions has gained a great deal of recognition over the last few years, led by realizations that certain screening initiatives, such as those for breast and prostate cancer, may be harming the very people they were designed to protect. In the fall of 2014, the second international Preventing Overdiagnosis Conference will be held, and the British Medical Journal will produce an overdiagnosis-themed journal issue. However, overdiagnosis in children has been less well described. This special article seeks to raise awareness of the possibility of overdiagnosis in pediatrics, suggesting that overdiagnosis may affect commonly diagnosed conditions such as attention-deficit/hyperactivity disorder, bacteremia, food allergy, hyperbilirubinemia, obstructive sleep apnea, and urinary tract infection. Through these and other examples, we discuss why overdiagnosis occurs and how it may be harming children. Additionally, we consider research and education strategies, with the goal to better elucidate pediatric overdiagnosis and mitigate its influence.

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“…More information about allergy testing can be found in a recent AAP clinical report on the subject. 18 Alternatively, the patient can be referred to an allergist-immunologist for allergy skin testing, interpretation of results, and education of the family about environmental triggers.…”

Section: Environmental Evaluation and Management For The Pediatric Pamentioning

confidence: 99%

“…Serum allergenspecific immunoglobulin E (IgE) antibody tests may be performed, or the patient may be referred to a board-certified allergist for allergy skin testing to identify indoor allergens that are most likely to be clinically relevant for a patient who meets National Asthma Education and Prevention Program criteria for persistent asthma, which include patients taking a long-term controller medication as well as patients having symptoms >2 days per week or nocturnal symptoms more than twice per month. 17 Serum IgE testing and allergy skin testing are both appropriate methods of assessing allergic sensitivities; neither is clearly better than the other in identifying clinically important sensitizations, 18 and there is no lower age limit for either of these tests.…”

Section: Introductionmentioning

confidence: 99%

Indoor Environmental Control Practices and Asthma Management

Matsui¹,

Abramson²,

Sandel³

et al. 2016

Pediatrics

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Indoor environmental exposures, particularly allergens and pollutants, are major contributors to asthma morbidity in children; environmental control practices aimed at reducing these exposures are an integral component of asthma management. Some individually tailored environmental control practices that have been shown to reduce asthma symptoms and exacerbations are similar in efficacy and cost to controller medications. As a part of developing tailored strategies regarding environmental control measures, an environmental history can be obtained to evaluate the key indoor environmental exposures that are known to trigger asthma symptoms and exacerbations, including both indoor pollutants and allergens. An environmental history includes questions regarding the presence of pets or pests or evidence of pests in the home, as well as knowledge regarding whether the climatic characteristics in the community favor dust mites. In addition, the history focuses on sources of indoor air pollution, including the presence of smokers who live in the home or care for children and the use of gas stoves and appliances in the home. Serum allergen-specific immunoglobulin E antibody tests can be performed or the patient can be referred for allergy skin testing to identify indoor allergens that are most likely to be clinically relevant. Environmental control strategies are tailored to each potentially relevant indoor exposure and are based on knowledge of the sources and underlying characteristics of the exposure. Strategies include source removal, source control, and mitigation strategies, such as high-efficiency particulate air purifiers and allergen-proof mattress and pillow encasements, as well as education, which can be delivered by primary care pediatricians, allergists, pediatric pulmonologists, other health care workers, or community health workers trained in asthma environmental control and asthma education.

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Allergy Testing in Childhood: Using Allergen-Specific IgE Tests

Cited by 125 publications

References 19 publications

Comparison of specific IgE detection by immunoblotting and fluorescence enzyme assay with in vivo skin prick test

Comparison of specific IgE detection by immunoblotting and fluorescence enzyme assay with in vivo skin prick test

Overdiagnosis: How Our Compulsion for Diagnosis May Be Harming Children

Indoor Environmental Control Practices and Asthma Management

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