Allergy Testing and Immunotherapy in an Academic Otolaryngology Practice: A 20‐year Review

Lane, Andrew P.; Pine, Harold S.; Pillsbury, Harold C.

doi:10.1067/mhn.2001.111602

Cited by 48 publications

(25 citation statements)

References 11 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We can estimate, however, that 80% of patients who are identified as having allergies by a physician will have a positive allergy skin test. 22,23 Furthermore, the number of affected participants in our dataset is consistent with the 2002 Chartbook on Trends in the Health of Americans, 18 which found that in patients ages 45 to 64 the prevalence of hay fever was 10.8%.…”

Section: Discussionsupporting

confidence: 69%

The Association Between Hay Fever and Stroke in a Cohort of Middle Aged and Elderly Adults

Matheson

Player²,

Mainous³

et al. 2008

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

Background: Asthma has been linked to stroke, but it is unknown if hay fever is related to stroke. This study was designed to investigate if there is an association between a reported history of hay fever and stroke during a 4.4-year study period.Methods: Analysis was performed of the Atherosclerosis Risk in Communities study, a cohort of middle aged and elderly adults. We examined the association of a reported history of hay fever to the development of stroke.Results: There were 9272 participants meeting our criteria, of which 125 had strokes. Of those with a history of hay fever, 2.2% had a stroke. Of those without a history of hay fever, 1.25% had a stroke. Participants with a history of hay fever had an unadjusted hazard ratio of 1.72 (95% CI, 1.08 -2.27) for stroke versus participants without hay fever. Risk of stroke remained significant (hazard ratio, 1.87 [95% CI, 1.17-2.99]) after controlling for age, sex, race, smoking status, body mass index, diabetes, hypertension, alcohol use, and hyperlipidemia.Conclusion: A history of hay fever seems to be a risk factor for stroke, and this association may be an area for future research and intervention.

show abstract

Section: Discussionsupporting

confidence: 69%

The Association Between Hay Fever and Stroke in a Cohort of Middle Aged and Elderly Adults

Matheson

Player²,

Mainous³

et al. 2008

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

show abstract

“…Loratadine, as an adjunctive therapy of atopic patients with acute sinusitis, was found to modestly improve sneezing and nasal obstruction (2115). It is also noteworthy to mention that half of the allergic patients with a history of sinus surgery and undergoing immunotherapy believed that surgery alone was not sufficient to completely resolve the recurrent episodes of infection related to their sinus disease (2116). Well-conducted clinical trials showing beneficial effects of oral H 1 -antihistamines in patients with CRS are lacking.…”

Section: Rhinosinusitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,801

1,761

View full text Add to dashboard Cite

“…(58,59) Strong correlation between the extent of disease on CT evaluation and the amount of eosinophils within the sinus tissue, as well as the presence of specific IgE antibodies (60) CT changes in patients with ragweed allergy (61) Increased percentage of NP in allergic patients (62) Immunotherapy increases success of surgery (31,63) especially in AFRS (64) Experimental study where nasal challenge with allergen has resulted in secondary maxillary sinus inflammation (26) Possible selection or referral bias (19)(20)(21)(22)(23) No increased percentage of allergy in NP patients (59,(65)(66)(67)(68)(69) Allergic rhinitis was less prevalent in those with worse disease on sinus CT scans (56) No increase of CRS during pollen season (27) The presence of allergy does not affect symptom severity, surgery likelihood, extent of disease on CT (33)(34)(35) Pediatric literature Increased incidence of atopic predisposition in pediatric patients with sinusitis (70, 71) Correlation of allergy and severity of sinus disease (70,72) ESS in children with AR does not have a poorer outcome. Treatment for the allergy before surgery may improve the success of ESS (73) Same percentage of positive allergy test in CRS and normal children (74) Same prevalence of CRS in atopic and nonatopic children (75) Percentage of opacification the same between allergic and nonallergic adults and children (76) ESS, endoscopic sinus surgery; AFRS, allergic fungal rhinosinusitis; AR, allergic rhinitis; CRS, chronic rhinosinusitis; NP, nasal polyps.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

Is chronic rhinosinusitis related to allergic rhinitis in adults and children? Applying epidemiological guidelines for causation

Georgalas

Vlastos

Picavet

et al. 2014

Allergy

View full text Add to dashboard Cite

The relationship between allergic rhinitis and chronic rhinosinusitis has been assessed in a number of observational and experimental studies. In this review, we attempt their synthesis and evaluation using the modified Bradford Hill guidelines for causation. Although there is no proof of causation, especially in the pediatric literature, an evaluation of underlying allergies is recommended at least as an initial measure of symptoms relief.Chronic inflammatory disorders of the upper airways are extremely prevalent and have a major impact on public health (1-5). Some review articles on chronic rhinosinusitis (CRS) have suggested that atopy predisposes to its development (6), because allergic rhinitis (AR) is a common coexisting disease in pediatric and adult patients with CRS (7).Despite the fact that acute and CRS have been shown to occur frequently in AR patients, a sound pathophysiologic mechanism has not been proven, and thus, the association between rhinosinusitis and AR remains controversial (8, 9). The hallmark of AR is an IgE-mediated (type I) hypersensitivity reaction to an inciting inhaled antigen (10) and, in some cases, an ingested food that causes a cross-reaction because of antigenic similarities between the inhalant and the food (11). On the other hand, the pathophysiology of CRS is more obscure. Although the clinical presentation and symptoms of CRSwNP and CRSsNP overlap, it appears that they are underlined by distinct pathophysiological mechanisms.For example, nasal polyps (NP) have significantly higher levels of eosinophil markers, while CRSsNP is characterized by a Th1 polarization with high levels of interferon-gamma (IFN-c) and transforming growth factor-beta (TGF-b). On the other hand, CRSwNP showed a Th2 polarization with high IL-5 and immunoglobulin (Ig) E concentration (12). One step further is to assess whether the Th2 phenotype in CRSwNP is the result of the atopic status, the presence of AR, or (allergic) asthma. We know that there are many parallels between NP and asthma (13). And even some specific gene polymorphisms present in CRS have also been found in asthma (14). Several reviews on the role of allergy in CRS, in both adults (11,15) and children (16), can be found in the recent English literature, where epidemiological and experimental studies are mentioned. However, a logical structure for investigating and defining causality in epidemiological studies, such as Bradford-Hill criteria for causation, has not been Allergy 69 (2014) 828-833

show abstract

Allergy Testing and Immunotherapy in an Academic Otolaryngology Practice: A 20‐year Review

Cited by 48 publications

References 11 publications

The Association Between Hay Fever and Stroke in a Cohort of Middle Aged and Elderly Adults

The Association Between Hay Fever and Stroke in a Cohort of Middle Aged and Elderly Adults

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Is chronic rhinosinusitis related to allergic rhinitis in adults and children? Applying epidemiological guidelines for causation

Contact Info

Product

Resources

About