Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects

Boyle, Julia; Eriksson, Malin; Stanley, Neil; Fujita, Tomoe; Kumagi, Y

doi:10.1185/030079906x112660

Cited by 58 publications

(41 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the PSQI, two participants in the TBI Sleep group and three participants in the non-TBI Sleep group reported using over-the-counter sleep aids within the last month. However, we are unaware whether participants used over-the-counter antihistamines, which increase REM latency and reduce REM 77 , during the day of testing. If a greater proportion of TBI individuals were on antihistamine medication during the day of testing, sleep architecture could have been impacted.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Mild Traumatic Brain Injury Chronically Impairs Sleep- and Wake-Dependent Emotional Processing

Mantua¹,

Henry

Garskovas

et al. 2017

Sleep

View full text Add to dashboard Cite

Study Objectives: A single traumatic brain injury (TBI), even when mild (ie, concussion), can cause lasting consequences. Individuals with a history of chronic (>1-year prior) mild TBI have an increased risk of mood disturbances (eg, depression, suicide). This population also has lingering sleep alterations, including poor sleep quality and changes in sleep stage proportions. Given these sleep deficits, we aimed to test whether sleep-dependent emotional memory consolidation is reduced in this population. We utilized a mild TBI group (3.7 ± 2.9 years post injury) and an uninjured (non-TBI) population. Methods: Participants viewed negative and neutral images both before and after a 12-hour period containing sleep ("Sleep" group) or an equivalent period of time spent awake ("Wake" group). Participants rated images for valence/arousal at both sessions, and memory recognition was tested at session two. Results: The TBI group had less rapid eye movement (REM), longer REM latency, and more sleep complaints. Sleep-dependent memory consolidation of nonemotional images was present in all participants. However, consolidation of negative images was only present in the non-TBI group. A lack of differentiation between the TBI Sleep and Wake groups was due to poor performance in the sleep group and, unexpectedly, enhanced performance in the wake group. Additionally, although the non-TBI participants habituated to negative images over a waking period, the TBI participants did not. Conclusions: We propose disrupted sleep-and wake-dependent emotional processing contributes to poor emotional outcomes following chronic, mild TBI. This work has broad implications, as roughly one-third of the US population will sustain a mild TBI during their lifetime.

show abstract

Section: Strengths and Limitationsmentioning

confidence: 99%

Mild Traumatic Brain Injury Chronically Impairs Sleep- and Wake-Dependent Emotional Processing

Mantua¹,

Henry

Garskovas

et al. 2017

Sleep

View full text Add to dashboard Cite

show abstract

“…19 -21 The residual effects of poor sleep, including impairment of attention, vigilance, working memory, and sensory-motor performance, are still present the next morning. 20,22 The detrimental central nervous system effects of first-generation H 1 -antihistamines on learning and examination performance in children and on impairment of the ability of adults to work, drive, and fly aircraft have been reviewed in detail in a recent review. 23 The use of first-generation H 1 -antihistamines in young children has recently been brought into question.…”

Section: First-generation H 1 -Antihistaminesmentioning

confidence: 99%

Pharmacology of Antihistamines

Church

2011

World Allergy Organization Journal

View full text Add to dashboard Cite

This article reviews the molecular biology of the interaction of histamine with its H 1 -receptor and describes the concept that H 1 -antihistamines are not receptor antagonists but are inverse agonists i.e. they produce the opposite effect on the receptor to histamine. It then discourages the use of first-generation H 1 -antihistamines in clinical practice today for two main reasons. First, they are less effective than second generation H 1 -antihistamines. Second, they have unwanted side effects, particularly central nervous system and anti-cholinergic effects, and have the potential for causing severe toxic reactions which are not shared by second-generation H 1 -antihistamines. There are many efficacious and safe second-generation H 1 -antihistamines on the market for the treatment of allergic disease. Of the three drugs highlighted in this review, levocetirizine and fexofenadine are the most efficacious in humans in vivo. However, levocetirizine may cause somnolence in susceptible individuals while fexofenadine has a relatively short duration of action requiring twice daily administration for full all round daily protection. While desloratadine is less efficacious, it has the advantages of rarely causing somnolence and having a long duration of action. Lastly, all H 1 -antihistamines have anti-inflammatory effects but it requires regular daily dosing rather than dosing 'on-demand' for this effect to be clinically demonstrable.

show abstract

“…3 The main concerns are their sedative properties and interference with rapid eye movement sleep. 3,4 Studies have shown poorer school performance in children with allergic rhinitis treated with sedating antihistamines, compared to children treated with non-sedating antihistamines and healthy children. 5 Sedating antihistamines have been found to be a cause of aviation accidents.…”

Section: Avoid Sedating Antihistaminesmentioning

confidence: 99%