Allergy markers in respiratory epidemiology

Baldacci, Sandra; Omenaas, Ernst; Oryszczyn, Marie-Pierre

doi:10.1183/09031936.01.17407730

Cited by 65 publications

(56 citation statements)

References 137 publications

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“…The numbers of eosinophil granulocytes in peripheral blood were determined by automated differential cell count after peroxidase staining. Blood eosinophilia was arbitrarily defined as eosinophil counts .400 per mL [22]. From the 429 children for whom reliable FE,NO values were obtained, specific IgE and eosinophil counts were available for 247 and 234 children, respectively.…”

Section: Specific Ige and Blood Eosinophilsmentioning

confidence: 99%

Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy

Brussee¹

2005

European Respiratory Journal

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Airway inflammation is an early feature of asthma. Early detection and antiinflammatory treatment may have important therapeutic impact. Exhaled nitric oxide is a noninvasive marker of airway inflammation. The current study investigated the association between exhaled nitric oxide and asthma, wheezing phenotypes, atopy and blood eosinophilia in a large group of 4-yr-old children from the general population.All children participated in the Prevention and Incidence of Asthma and Mite Allergy study, a birth cohort study of high-risk (atopic mother) and low-risk children in the Netherlands. Nitric oxide levels were successfully determined in 429 children.Although there was overlap in the distribution of values of children with and without asthma or atopy, mean values were higher in children with atopy or doctor's diagnosed asthma (geometric mean (ppb) 9.4 and 10.0, respectively) as compared to those without (7.7 and 7.9). Values were highest in atopic symptomatic children. Values were not associated with wheezing phenotype or blood eosinophilia.This study is one of the few large-scale epidemiological studies among 4-yr-old children from the general population showing that children with symptoms of asthma and atopy have higher levels of exhaled nitric oxide than those without.

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Section: Specific Ige and Blood Eosinophilsmentioning

confidence: 99%

Exhaled nitric oxide in 4-year-old children: relationship with asthma and atopy

Brussee¹

2005

European Respiratory Journal

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“…27 Moreover, these regression models were built separately in three groups of family members (parents, pediatric offspring o16 years of age, adult offspring X16 years of age), provided the effects of age and sex on the phenotypes analyzed may vary in adults and children. 28 Each phenotype was adjusted for the significant position and covariates effects and standardized within each group of subjects. All computations were done with the SAS package 8.2.…”

Section: 26mentioning

confidence: 99%

Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands

et al. 2004

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Asthma is a complex disease, associated with biological and physiological phenotypes including immunoglobulin E (IgE) levels, sum of positive skin prick tests to allergens (SPTQ), eosinophil counts (EOS) and percent predicted forced expiratory volume in 1 s (%FEV 1 ). We investigated the patterns of familial correlations and the inter-relationships of these four quantitative phenotypes, using the general class D regressive model, in 320 French EGEA nuclear families ascertained through 204 offspring (set A) and 116 parents (set B). Familial correlations of IgE and SPTQ were consistent with a model including no spouse correlation and equal parent -offspring and sib -sib correlations (q PO ¼ q SS ¼ 0.25 for IgE and 0.15 for SPTQ), this model being compatible with an additive polygenic model in the whole sample and the two family subsets A and B. Different patterns of familial correlations of EOS and %FEV 1 were observed in these two sets. In set A, the best fitting model included no spouse correlation and equality of parent -offspring and sib -sib correlations (q PO ¼ q SS ¼ 0.14 for EOS and 0.23 for %FEV 1 ). In set B, EOS had only a significant q SS of 0.28, while %FEV 1 had significant q MO of 0.28 and q SS of 0.16. Analysis of shared familial determinants between these phenotypes indicated an overlap of at most 30% in q FO for IgE and SPTQ and in both q FO and q MO for IgE and EOS, while determinants of %FEV 1 and atopy-related phenotypes appear distinct. These results may have implications for further linkage and association studies with genetic markers.

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“…This is the prime reason why we started the series "Contributions from the European Respiratory Monograph" in the present issue of the Journal. The ®rst contribution is the one by S. Baldacci et al on "Allergy markers in respiratory epidemiology" [1]. From this issue onwards, we will have such a contribution each month.…”

mentioning

confidence: 97%