Allergy Induced by Immunization With Tetanus Toxoid

Evidence that Food Proteins in Vaccines Cause the Development of Food Allergies and Its Implications for Vaccine Policy

“…In 1940, Cooke et al [5] describe induction of allergy by a tetanus vaccine. In 1952, Ratner et al [6] were concerned about the possibility of sensitization to egg following the administration of influenza vaccines that are manufactured using chicken eggs.…”

Tetanus Prophylaxis and Circulating Antitoxin in Men and Women

“…A further reason for the change of medium was that mild allergic symptoms have been reported in a few persons, mainly after second injections of toxoids prepared from broth containing Witte peptone (Whittingham, 1940;Parish andOakley, 1940. Cooke, Hampton, Sherman andStull, 1940;Cunningham, 1940); these manifestations are apparently due to the peptone. We do not claim that the substitution of a medium which does not contain Witte peptone will obviate all allergic symptoms, although so far none has been reported to us.…”

Telangiectasia Macularis Eruptiva Perstans

“…In 1940 Cooke 15 reported on allergy induced by immunization with tetanus toxoid, and in the same year Whittinghamla and Cunningham " reported on anaphylaxis following administration of tetanus toxoid. In 1942 Sulzberger 18 reported a case of chronic urticaria of over six months' duration which began three days after an initial injection of tetanus toxoid.…”