Allergy caused by ingestion of zucchini (Cucurbita pepo) : Characterization of allergens and cross-reactivity to pollen and other foods

Medicinal bioactivites and allergenic properties of pumpkin seeds: review upon a pediatric food anaphylaxis case report

“…For Cucurbita sp. pulp allergy, possible allergens could be profilin (15 kDa protein, Cuc p 2, Cuc ma 2), LTP (8.9 kDa protein), cross-reacting carbohydrate determinants and zucchini-specific proteins of molecular weight of 16-17 kDa and of 41.5 kDa (42,43,48,49). González De Olano et al identify an 18 kDa protein, corresponding to cyclophilin (Cuc ma CyP) as a relevant allergen for oral allergy syndrome to pumpkin (50).…”

“…González De Olano et al identify an 18 kDa protein, corresponding to cyclophilin (Cuc ma CyP) as a relevant allergen for oral allergy syndrome to pumpkin (50). toms or stridor (43). The first case of pediatric food anaphylaxis to pumpkin pulp (C. maxima) was published by Hagendorens in 2009 (44).…”

“…Cucurbita sp. allergy can be isolated (43[three of the four cases]-46,48,49), but in some cases is correlated with clinical cross-allergenicity to other fruits of the cucurbitaceous family (cucumber, melon, and/or watermelon) (42,43,50). Pumpkin (58,59).…”

Plant Food Allergies: A Suggested Approach to Allergen-Resolved Diagnosis in the Clinical Practice by Identifying Easily Available Sensitization Markers

“…In one study, the few patients monosensitized to profilin did not report any relevant symptom following the ingestion of plant-derived foods [41], and another one concluded that IgE cross-reactive against food profilins has no or very little clinical relevance [43]; on the other hand, profilin has been involved in the so-called ‘birch-mugwort-celery-spice’ syndrome and in adverse reactions to Apiaceae [44,45,46,47], hazelnut [11], Rosaceae [14, 48], tomato [49], pumpkin seed [50], zucchini [51], lychee [52], pineapple and banana [53], persimmon [54] and melon [55]. Altogether, these studies suggest that probably only a limited proportion of subjects sensitized to profilin develop clinical allergy.…”

Purification and Characterization of 31-kDa Palm Pollen Glycoprotein (Ela g Bd 31 K), Which is Recognized by IgE from Palm Pollinosis Patients

“…It has been reported that allergens puriˆed from plant materials are often glycoproteins, to which the plant complex type N-glycans bearing b 1-2 xylose and W or a1-3 fucose residue(s) are bound. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] Several groups (Garcia-Casado et al, 7) Ohsuga et al, 8) F äotisch et al, 9) van Ree et al 10) ) have reported that b 1-2 xylose and W or a1-3 fucose residues are essential in the recognition of the allergenic glycoproteins by allergic human IgE, postulating that the plant complex type N-glycans could be an important epitope in the allergenic response. On the other hand, Hijikata et al…”