Allergy and Oxidative Stress

Twardoch, Magdalena; Lodwich, Magdalena; Mazur, Bogdan

doi:10.18794/aams/41812

Cited by 4 publications

(4 citation statements)

References 32 publications

(56 reference statements)

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“…Most likely, this is the first observation that the induction of LAR symptoms may produce a systemic antioxidant response. There is evidence that oxidative stress plays a significant role in atopic disease, for example, in AR [21, 22]. The decrease in antioxidant enzymes in patients with SAR was also observed in the present study.…”

Section: Discussionsupporting

confidence: 87%

Potential Differences between Local and Systemic Allergic Rhinitis Induced by Birch Pollen

Bożek

Fiolka

Wojtys

et al. 2020

Int Arch Allergy Immunol

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Introduction: Different endotypes of rhinitis are known, but its pathomechanism has not been conclusively established. For example, the precise difference between systemic allergic rhinitis (SAR) and local allergic rhinitis (LAR) is still being checked. Comparison of patients with LAR and with allergies to birch of those with intermittent allergic rhinitis, same allergy, or with non-allergic rhinitis (NAR) was the purpose of this study. Methods: Twenty-six patients with LAR, 18 with SAR and allergy to birch, and 21 with NAR were included. Patients who met the inclusion criteria were selected to undergo the following procedures at baseline: medical examinations, nasal provocation test (NPT), detection of nasal-specific IgE to birch as well as basophil activation test (BAT). All immunological parameters were detected before and after NPT. Results: Concentration of nasal IgE to Bet v1 increased comparably in the LAR and SAR groups after NPT to birch as follows: in 21 (81%) patients with LAR, 14 (78%) with SAR, and in everyone in the NAR group. Serum concentration of allergen-specific IgE to Bet v1 increased significantly from a median of 20.7 (25–75% interval: 11.2–35.6) IU/mL to 29.9 (13.6–44.1) (p = 0.028) after NPT in patients with SAR. Allergen-specific IgE to Bet v1 was absent in all patients with LAR and NAR before and after NPT. BAT with Bet v1 was positive in 22 (85%) patients with LAR, in 14 (78%) with SAR, and 2 (9.5%) with NAR. Conclusion: These obtained data suggest there are no potential mechanisms that could explain LAR compared to SAR.

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Section: Discussionsupporting

confidence: 87%

Potential Differences between Local and Systemic Allergic Rhinitis Induced by Birch Pollen

Bożek

Fiolka

Wojtys

et al. 2020

Int Arch Allergy Immunol

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“…Since mitochondria are one of the main sources of ROS in the body, we were interested to look for associations between antimitochondrial antibodies (AMA) (AC-21 pattern) and the activity of SOD isoenzymes. It is known that the mitochondrial matrix predominantly contains the manganese isoform of superoxide dismutase (MnSOD) [ 102 , 103 ]. Our hypothesis was not confirmed.…”

Section: Discussionmentioning

confidence: 99%

Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies

et al. 2021

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IntroductionOxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA.Material and methodsWe examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid concentration (UA), were also measured and the oxidative stress index (OSI -index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA).ResultsThe presence of ANA in women was associated with lower physical activity (p=0.036), less frequent smoking (p=0.007) and drinking of alcohol (p=0.024) accompanied by significant changes in SOD isoenzymes activity (p<0.001) and a higher uric acid (UA) concentration (p<0.001). In ANA positive males we observed lower concentrations of PSH (p=0.046) and increased concentrations of MDA (p=0.047).ConclusionsThe results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.

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“…Glutathione reductase is an enzyme found in both the cytosol and mitochondria of the cell. It participates in maintaining the correct concentration of the reduced form of glutathione in the body, catalysing the following reaction: GS-SG+NADPH+H+→2GSH+NADP+ (GS-SG, oxidized glutathione) [32]. Reduced glutathione has strong antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

2020

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Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol® (modified Biolasol®), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se4+ ions at a dose of 1 µg/L into the Biolasol® preservation solution in the form of Na2SeO3 caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se4+ on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol® modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO32−) during ischemia/reperfusion.

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Allergy and Oxidative Stress

Cited by 4 publications

References 32 publications

Potential Differences between Local and Systemic Allergic Rhinitis Induced by Birch Pollen

Potential Differences between Local and Systemic Allergic Rhinitis Induced by Birch Pollen

Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies

Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

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