Allergy and Ménière’s disease

Derebery, M. Jennifer; Berliner, Karen I.

doi:10.1007/s11882-007-0069-0

Cited by 13 publications

(11 citation statements)

References 37 publications

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“…Moreover, Rask-Andersen et al [1994] created the term 'saccitis' to identify the presence of signs of cytotoxic interactions between immune system and ear epithelial cells. Accordingly, serum autoantibodies against internal ear antigens as well as circulating immunocomplexes have been reported in MD patients [Hsu et al, 1990;Derebery, 1997;Yoo et al, 2001;Riente et al, 2004]. Furthermore, MD patients show many features of autoimmune disease, such as a positive family in some histories, the association with certain HLA loci (Cw7, A1, B8) as well as good response to steroid therapy [Shea, 1983;Xenellis et al, 1986, Garcia-Purriños et al, 2005.…”

Section: Introductionmentioning

confidence: 99%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

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Objective/Hypothesis: The aim of this prospective study is to evaluate the possible association between Ménière’s disease (MD) and autoantibodies. Methods: Fifty-five patients with definite MD (51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. Results: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects (23.6%) had 1 or more elevated serum autoantibody levels. Conclusions: Based on our data we speculate that there is a more than a chance association between MD and ‘autoimmunity’, thus suggesting a hypothetical role of the immune system in MD pathogenesis. In other words, a pathogenetic role of an ‘immune dysregulation’ in MD patients can be hypothesized.

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Section: Introductionmentioning

confidence: 99%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

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“…The systemic immune challenge resulted in an allergic reaction within the inner ear leading to endolymphatic hydrops, which has been previously reported [3][4][5][6][7][8]. From then on the vertigo would occur during or after meals, and the associated tinnitus, aural pressure, hearing loss, and other MD symptoms emerged.…”

Section: Discussionmentioning

confidence: 79%

“…Allergy, metabolic disturbances, trauma, and inflammatory disorders are all possible contributory factors [2]. Allergy also plays a role in the production of the symptoms of MD in adult disorders [3][4][5][6][7][8]. Besides allergy, dysautonomia also contributes to the symptoms of MD in adult patients [9,10].…”

Section: Introductionmentioning

confidence: 99%

Vertigo with dysautonomia and serious allergy: An unusual case of juvenile Ménière's disease

Gao

2015

International Journal of Pediatric Otorhinolaryngology

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“…In some other studies, MD was associated to particular human leucocyte antigen haplotypes like thyroid autoimmunity [19]. Other studies have incriminated the effect of inhalant and food allergy to MD [20].…”

Section: Discussionmentioning

confidence: 98%

Is Meniere Disease Caused by a Pathological Immune Response?

Selmani¹,

Pyykkö²,

Ashammakhi³

2014

IJOHNS

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The etiology of Meniere disease (MD) is unknown. Among the several factors which can provoke the disease is a pathological immune response. Objective: To investigate whether MD is due to a pathological immune reaction. Materials and methods: Immunological assay (IA) was evaluated in a consecutive study on 159 patients with MD (mean age 47.8. years) and the results compared with those from 26 patients operated on because of vestibular schwannoma (VS, mean age 54.1 years), who served as a control group. In cases of MD, transtympanic electrocochleography (ECoG) and hearing threshold were measured. Results: The average hearing level (HL) in the affected ears of patients with MD was 30 dB. Evidence of abnormal plasma protein pattern was found in 127 MD patients (80%). Elevations were found in β1-globulin (54.5%), β 2 -globulin (26.5%), α 2 -globulin (34.3%), γ-globulin (17.3%), complement (CH100, 36.4%) and antinuclear antibodies (ANA, 43.4%). The onset of the disease did not correlate with the level of the plasma protein neither with the level of IgG titers. Conclusion: Elevated certain plasma proteins in patients with Meniere's disease could be a sign that Meniere's disease is a consequence of pathological immune reaction.

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Allergy and Ménière’s disease

Cited by 13 publications

References 37 publications

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Vertigo with dysautonomia and serious allergy: An unusual case of juvenile Ménière's disease

Is Meniere Disease Caused by a Pathological Immune Response?

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