Allergy and Laryngeal Disease

Dixon, Hamilton S.

doi:10.1016/s0030-6665(20)31028-8

Cited by 11 publications

(5 citation statements)

References 7 publications

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“…The bath used for the repeat challenge was a Western-style bath, which did not create enough of a temperature difference to induce aphonia. Anaphylactic reactions are quite dramatic, and those involving the larynx can quickly obstruct the airway (Dixon, 1992). We strongly recommend a laryngeal study in case of sudden onset aphonia.…”

Section: Discussionmentioning

confidence: 95%

Sudden onset aphonia caused by a Japanese-style bath

1998

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An 86-year-old man was referred by his family physicianto our clinic because of sudden onset aphonia immediately after a Japanese-style bath. On examination, the only abnormality was aphonia, with an otherwise normal physical examination. However, we found vocal fold oedema on laryngeal fibrescopy. For treatment, he was immediately given 30 mg prednisolone intravenously. Twelve hours after injection the oedema had completely disappeared and his aphonia had resolved. The patient was healthy for three months after returning home. However, at the beginning of a cold winter night he again complained of sudden onset hoarseness, after taking a Japanese-style bath.Japanese-style baths are completely different from Western-style baths. There is a temperature difference of almost 30°C between the inside and outside of a bath; the transition may represent a type of physical exercise in elderly and exhausted individuals. This difference could cause a cold or heat-induced allergic reaction. We strongly recommend a laryngeal study in case of sudden onset aphonia.

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Section: Discussionmentioning

confidence: 95%

Sudden onset aphonia caused by a Japanese-style bath

1998

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“…3 Many of these patients, however, have frequent symptoms of allergic rhinitis and note an exacerbation of their laryngeal symptoms that accompanies their nasal and sinus symptoms. 4 Jackson-Menaldi et al 5 described 17 patients in a community otolaryngology practice who had allergic disease confirmed by skin testing. All of these patients complained of concomitant laryngeal symptoms such as hoarseness and voice strain.…”

mentioning

confidence: 99%

“…Frequently, these patients are diagnosed with laryngopharyngeal reflux disease 3 . Many of these patients, however, have frequent symptoms of allergic rhinitis and note an exacerbation of their laryngeal symptoms that accompanies their nasal and sinus symptoms 4 . Jackson‐Menaldi et al 5 described 17 patients in a community otolaryngology practice who had allergic disease confirmed by skin testing.…”

mentioning

confidence: 99%

Laryngeal Effects of Antigen Stimulation Challenge with Perennial Allergen Dermatophagoides Pteronyssinus

Reidy¹,

Dworkin²,

Krouse³

2003

Otolaryngol.--head neck surg.

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OBJECTIVE: We conducted a pilot study to assess the effects of antigen stimulation on the appearance and function of the larynx. STUDY DESIGN AND SUBJECTS: The prospective, double-blind, randomized study included 9 adult patients with a skin-prick test positive for Dermatophagoides pteronyssinus. MAIN OUTCOME MEASURES: Subjects were blindly challenged via nebulizer with either an active antigenic suspension or placebo. Baseline and 30-minute evaluations of the larynx were performed. Assessments included subjective voice and video-stroboscopic assessments, acoustic analysis of voice, speech aerodynamic testing, and allergy and voice handicap questionnaires. RESULTS: Although both inflammation and increased mucus were noted, there were no significant differences between the antigen- and placebo-exposed subjects on any of the measures obtained. CONCLUSIONS: Our preliminary investigation was not successful in demonstrating a direct causal relationship between antigen exposure and physical or functional changes in the larynx. Future studies will involve modifications to our current methodology, including increasing the concentration of antigen, prolonging the exposure time, and observing for late phase responses.

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“…The specific diagnosis of allergy has long been neglected as a possible cause of intermittent dysphonia. 1 Nonspecific pharmacotherapy has been shown to be ineffective in many of these cases. In more than 30 years of extensive experience treating allergy, I have not uncommonly seen patients with dysphonia who represent diagnostic and treatment dilemmas.…”

mentioning

confidence: 99%

“…The purposes of this study are (1) to add to the body of knowledge that delayed food allergy can be diagnosed and treated, (2) to show that provocation/neutralization skin testing is an objective test and a useful tool, (3) to demonstrate a relationship between dysphonia and food hypersensitivity through reproducibility in testing, (4) to present the results of using state-of-the-art technology to objectively measure changes in the vocal folds, (5) to measure changes in the quality of the voice and record laryngeal airflow and resistance measurements during provocation/neutralization food skin testing, and (6) to measure the success of specific food elimination.…”

mentioning

confidence: 99%

Dysphonia and Delayed Food Allergy: A Provocation/ Neutralization Study with Strobovideolaryngoscopy

Dixon

1999

Otolaryngol.--head neck surg.

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In most cases the cause of intermittent dysphonia remains undiagnosed. This descriptive study explores the relationship between this problem and delayed food allergy. Double-blind intradermal provocation/neutralization skin tests to food antigens were used to do 12 tests in 10 subjects with food allergies. Strobovideolaryngoscopy was used to document changes in the vocal folds and in the quality of the voice. Double-blind measurements of signs and symptoms, digital audio recordings of the voice for perceptual and acoustic analysis, and aerodynamic laryngeal airflow and resistance measurements were done. The cause of dysphonia appeared to be associated with an increase in thick mucus production and irregular and asymmetric glottic edge edema of the vocal folds. Elimination of the positive specific foods resulted in cessation of dysphonia in all the test subjects. Statistical analysis was not done because of the lack of parametric data for paired analysis, lack of sufficient data points for resampling statistics, and the small sample size.

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Allergy and Laryngeal Disease

Cited by 11 publications

References 7 publications

Sudden onset aphonia caused by a Japanese-style bath

Sudden onset aphonia caused by a Japanese-style bath

Laryngeal Effects of Antigen Stimulation Challenge with Perennial Allergen Dermatophagoides Pteronyssinus

Dysphonia and Delayed Food Allergy: A Provocation/ Neutralization Study with Strobovideolaryngoscopy

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