Allergy and Immunology

Talmage, David W.

doi:10.1146/annurev.me.08.020157.001323

Cited by 222 publications

(108 citation statements)

References 0 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…This meant that an Ab's specificity is dictated by its amino acid sequence, and is thus determined before encountering the Ag. These findings were fully in accord with the radical proposal made a few years earlier that Ab-producing cells differ in the Ab they make and that an Ag acts by selectively stimulating only those cells that make a matching Ab (8,9). This cell or clonal selection hypothesis amounted to the view that before encountering Ag, the Ab molecules made by a B cell have a particular amino acid sequence and, as a consequence, a singular binding site that fits one Ag and perhaps a few similar ones.…”

Section: Ab Specificitysupporting

confidence: 89%

Evolving concepts of specificity in immune reactions

Eisen

Chakraborty

2010

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Our goal is to provide a perspective on current understanding of the origins of specificity in immune reactions, a topic that has intrigued scientists for over a century. A fundamental property of adaptive immune responses is the ability to discriminate among an immense variety of substances by means of antibodies (Abs) and Ab-like receptors on T lymphocytes [T-cell receptors (TCRs)], each able to bind a particular chemical structure [the antigen (Ag)] and not, or only weakly, similar alternatives. Evidence has long existed, however, and has grown, especially recently, that while exhibiting remarkable specificity, many individual Abs and TCRs can also bind a variety of very different ligands. How can Ag recognition by these receptors exercise the great specificity for which they are renowned and yet react with a variety of different ligands (degeneracy)? We critically consider the mechanistic bases for this specificity/degeneracy enigma and also compare and contrast Ag recognition by Abs and TCRs.T cells | peptide-MHC complexes | receptor-ligand interactions | antibody isomerism

show abstract

Section: Ab Specificitysupporting

confidence: 89%

Evolving concepts of specificity in immune reactions

Eisen

Chakraborty

2010

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…When an antigen enters the body, it unites with an antibody that just happens to fit it, the antigen-antibody complex is taken up by a cell and the antibody somehow acts as the template for the formation of more of itself. David Talmage 5 and Macfarlane Burnet 6 recognized that this theory would make more sense if the postulated natural antibodies were located on the surface of what we now call B lymphocyte cells. If each cell were endowed with only one sort of antibody specificity, then the antigen could select one lymphocyte out of a repertoire, cause its clonal division and stimulate antibody production and secretion (Fig.…”

Section: One B Cell Produces One Antibodymentioning

confidence: 99%

The double helix and immunology

Nossal

2003

Nature

View full text Add to dashboard Cite

genomic insult. This integrated field is now deciphering the complex regulatory pathways transduced by signalling mechanisms that detect DNA damage and/or arrested DNA replication. As these pathways become better understood, parallel technological gains in gene therapy and therapeutic intervention by rational drug design will offer new strategies for blocking the unwanted consequences of DNA damage, especially cancer.We must remember, however, that while evolution could not have transpired without robust cellular mechanisms to ameliorate the most serious consequences of spontaneous and environmental DNA damage, the process of evolution mandates that the genetic diversification on which Darwinian selection operates be maintained constantly. Thus, life is necessarily a delicate balance between genomic stability and instability -and of mutation and repair. s s

show abstract

“…Its conceptual underpinnings have been traced to Elie Metchnikoff's turnof-the-century work on the phagocyte (19), but its modern formulation is generally credited to the work of Talmage (20), Burnet (21), and Medawar (22). As is by now well known, their work established the idea that during the neonatal period the immune system can learn to tolerate Ags that are normally present in the self.…”

Section: The Trouble With "Self"mentioning

confidence: 99%

Cutting Edge Commentary: A Copernican Revolution? Doubts About the Danger Theory

Vance

2000

The Journal of Immunology

View full text Add to dashboard Cite

The immune system is often said to function by “self-nonself” discrimination. Recently, some have argued that it actually detects “danger” or “strangers.” There are problems with all of these points of view. Given that the immune system has been cobbled together throughout evolution and uses a diverse array of innate and adaptive defense mechanisms, it may not be possible to account for immunity within one “paradigm” or another.

show abstract

Allergy and Immunology

Cited by 222 publications

References 0 publications

Evolving concepts of specificity in immune reactions

Evolving concepts of specificity in immune reactions

The double helix and immunology

Cutting Edge Commentary: A Copernican Revolution? Doubts About the Danger Theory

Contact Info

Product

Resources

About