Allergische Hautreaktionen und Arzneimittelgruppen

Kh, Schulz

doi:10.1007/bf00522878

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Such a risk, which has been documented in other studies (3,16), may be almost annihilated if oral instead of parenteral prophylaxis is chosen (2,5). Such a risk, which has been documented in other studies (3,16), may be almost annihilated if oral instead of parenteral prophylaxis is chosen (2,5).…”

Section: Discussionmentioning

confidence: 90%

“…Judging from the present relatively small material, the used regimen of monthly intramuscular injections of depot penicillin carries no alarming risk of allergic reactions. Such a risk, which has been documented in other studies (3,16), may be almost annihilated if oral instead of parenteral prophylaxis is chosen (2,5). However, the advantage of controlled compliance of patients on parenteral prophylaxis may outweigh the increased risk of allergic reactions associated with this form of drug admini-stration.…”

Section: Discussionmentioning

confidence: 98%

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Antibodies to penicillin in children receiving long‐term secondary prophylaxis for rheumatic fever

Strannegård¹,

Majeed²,

Ahlstedt³

1987

Allergy

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The occurrence of IgE and IgG antibodies to penicillin G and V in children on long-term treatment with penicillin as secondary prophylaxis for rheumatic fever was studied using Phadebas RAST (Pharmacia Diagnostics, Uppsala, Sweden) and ELISA respectively. The duration of the prophylaxis ranged between 1.5 months and 5 years (mean 1.8 years). Of 18 patients who had been given penicillin for more than 1.5 months, two had IgE antibodies and 12 had IgG antibodies to penicillin. Patients with acute rheumatic fever who had not yet received long-term treatment with penicillin had antibodies of the IgG class in two out of 12 cases. The patients gave no history of adverse reactions to the penicillin injections and there were no signs of immune complex-mediated disease. The two children who had IgE antibodies were switched to oral erythromycin instead of the penicillin injections. Penicillin is the drug of choice in the prophylaxis of rheumatic fever and can apparently be safely given as intramuscular injections of depot-penicillin to prevent recurrences of the disease and ensuing cardiac damage.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Antibodies to penicillin in children receiving long‐term secondary prophylaxis for rheumatic fever

Strannegård¹,

Majeed²,

Ahlstedt³

1987

Allergy

View full text Add to dashboard Cite

show abstract

“…In different populations the frequency of penicillin hypersensitivity varies between 1 and 10 % (9). The sensitizing effect of penicilli.n seems to vary with different modes of administration, intra muscular injections giving a higher frequency of sensitization than oral medication (12).…”

mentioning

confidence: 99%