Allergieteste mit natürlichem und synthetischem ACTH

Non-Specific Effects of Synthetic Corticotrophin Polypeptides

“…The evidence obtained in this study points to gelatin, used as stabilizer for this extractive ACTH preparation, as the likeliest agent responsible for the allergic reactions observed. M aeder and Schwarz-Speck have been able to trace allergic reactions in patients with an allergy to semi-purified commercial ACTH to species-specific contaminants of such prepa rations; they have also shown that /51_24-corticotrophin identical with that used in the present study and highly purified natural ACTH were unable to elicit true positive reactions in such patients (11). Likewise, H ofmann et al (1) have not succeeded in producing antibody to synthetic /^-^-corticotrophin whereas antibody to the protected polypeptide was obtained with relative ease.…”

“…However, with the hormonally active peptides, the permeabilizing effects appear with doses correspond ing roughly to those required to achieve the typical hormonal action in man and animal. This fact should be taken into account wherever infiltrations occur at the site of injection of synthetic corticotrophin, and has already been used successfully by M aeder and Schwarz as a means of distinguishing between false and true positive skin reactions in patients allergic to natural ACTH (11).…”

Immune Responses to Treatment With Natural and Synthetic Acth in Bronchial Asthma

“…Most of the allergic reactions then reported were probably the result of sensitization against the contaminating foreign proteins in the preparations rather than against the hormone character per se (22). Most of the allergic reactions then reported were probably the result of sensitization against the contaminating foreign proteins in the preparations rather than against the hormone character per se (22).…”

“…Reactions against ACTH were rather commonly noted during the first decade of therapy with pituitary extracts of animal origin. Most of the allergic reactions then reported were probably the result of sensitization against the contaminating foreign proteins in the preparations rather than against the hormone character per se (22). Since the sixties, when highly purified corticotropine came into use, such reactions are less common.…”