Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy

Abstract

SummaryLow-level alloreactivity between mother and fetus may provide stimulation for fetal T helper type 1 (Th1) cell immune maturation. This study explored the effects of human leucocyte antigen (HLA) mismatch on materno-fetal interactions detected as cytokine responses and lymphoproliferation in mixed lymphocyte reactions, and whether this was altered in allergic women (n = 62) who have a Th2 propensity compared with non-allergic women (n = 65). HLA-DRb1 mismatch was associated with significantly increased Th1 interferon (IFN)-g, Th2 interleukin (IL)-13 and lymphoproliferative responses by both mothers and fetuses. Allergic women showed significantly lower IFN-g Th1 production in response to HLA-DRb1 mismatch. The infants of these women also showed significantly lower IL-10 and lower IFN-g production relative to IL-13. Both HLA-DRb1 mismatch and maternal allergy had significant independent effects on maternal IFN-g Th1 responses. Maternal allergy modifies HLA-mediated alloreactivity between the mother and the fetus, reducing Th1 activation. This may affect the cytokine milieu at the maternofetal interface and could be implicated in the attenuated Th1 responses observed commonly in infants of atopic mothers.

Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

“…The non-allergic women showed decreased allergen-induced IL-13 secretion in late gestation while the IL-13 secretion remained high in the allergic women [151]. Furthermore, allergic women had reduced IFN-γ and IL-10 production in response to fetal and paternal alloantigens during and after pregnancy [134][135][136].…”

“…Allergic women had reduced IFN-γ and IL-10 production in response to fetal and paternal alloantigens during and after pregnancy [134][135][136]. Furthermore, low IFN-γ and high IL-4 and IL-5 production has been observed in allergic individuals after stimulation with bacterial antigens, i.e.…”

Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women

“…Further, allergic women have showed significantly lower IFN-γ and relative Th1/Th2 responses to fetal HLA-DRβ1 mismatch during pregnancy (Prescott et al 2009). In a previous study, we found similar responses toward paternal and unrelated pooled antigens in allergic and non-allergic women in the same cohort as in the present study (Persson et al 2008).…”

“…Furthermore, a lower relative Th1/Th2 production was observed in allergic pregnant women by mixed leukocyte reactions (MLR) using irradiated cord blood cells as a proxy for fetal antigens (Breckler et al 2008;Prescott et al 2009). We have previously developed an MLR using inactivated paternal cells as a proxy for allogeneic fetal cells (Ekerfelt et al 1997).…”

Intestinal Microbiocenosis, Food Tolerance and Food Allergy. Current State of a Problem

“…К таким факторам относят матерей-атопиков, а также измене-ния в составе кишечной микрофлоры. Как показывают данные современных исследований, среда оказывает эпигенетическое влияние на экспрессию генов иммун-ного ответа у матери, что в свою очередь может влиять на иммунный ответ ребенка [2][3][4], повышая риск реали-зации генетической предрасположенности к заболева-ниям, в т. ч. и аллергическим.…”