Allergic sensitization to storage dust mites: a prospective study of patients with respiratory allergy

Marques, Maria Luís; Rezende, I; Cunha, Inês; Gouveia, Joana; Santos, Filipe; Falcão, Inês; Cunha, Liliana; Falcão, Helena

doi:10.23822/eurannaci.1764-1489.178

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…In fact, the authors identified SM sensitisation in urban home environments as well [11]. Also, a prospective study published in 2022 in our country showed that 61.5% of the respiratory allergic patients presented positivity for at least one SM, with Lep d being the most prevalent one [12]. These studies report significant associations between SM sensitisation and asthma and rhinitis.…”

Section: Discussionmentioning

confidence: 84%

“…All 32 patients had sensitisation to other SM ( Tyrophagus putrescentiae and Glycyphagus domesticus ), evaluated with SPT. Those are assessed in a regularly basis in our allergy consults due to its prevalence in house dust in southern Portugal [8, 12]. It is well known that there is an important cross-reactivity between these SM and Lep d demonstrated among Gly d 2, Tyr p 2, and Lep d 2, but little cross-reactivity is reported between those and Der p 2 [64].…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, according to increasing evidence, some SMs have penetrated the habitats of HDM [5][6][7][8]. Studies from different countries have shown that IgE-mediated allergy to SM, with Lep d being the most prevalent one, is of considerable importance in both rural and urban populations [9][10][11][12][13][14]. A study conducted along the portuguese region analysed dust samples from houses throughout the territory to better understand the intensity of allergic exposure to HDM and SM.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Relevance of Lepidoglyphus destructor Sensitisation in Allergic Rhinitis: Nasal Provocation Test as in vivo Assessment

Matos Semedo,

Martins,

Tomaz

et al. 2024

Int Arch Allergy Immunol

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Background: Dust mites are the leading cause of respiratory allergic diseases worldwide. Allergy to storage mites (SMs) has mostly been related to occupational exposures. However, recent studies have shown that sensitisation to SM, such as Lepidoglyphus destructor (Lep d), is of considerable importance also in urban populations, with high prevalence in dust samples of domestic environments. Co-sensitisation between house dust mites (HDMs) and SM is now regarded as very frequent in some regions, and cross-reactivity between them seems to be narrow. Therefore, SM allergenic capacity is increasingly a subject of study. The nasal provocation test (NPT), as an in vivo technique, could be considered the gold standard for the clinical relevance assessment of an allergen, in polysensitised rhinitis patients. Objective: The objective of this study was to analyse the clinical relevance of the SM Lep d, by assessing the relationship between in vivo sensitisation and expression of allergic respiratory disease in an urban setting. Patients and Methods: In our study, we enrolled a total of 32 allergic patients with rhinitis (with or without asthma) with proven sensitisation by skin prick test (SPT) and specific IgE (sIgE) to HDMs and/or SM. Patients underwent NPT with Lep d using subjective (Lebel Symptom Score Scale) and objective measurements (peak nasal inspiratory flow [PNIF]) for assessment of nasal response. Results: Most of the patients with positive SPT and sIgE to Lep d had a positive NPT (24/27; 89%). True Lep d allergy, assessed by a positive NPT, could be predicted by a SPT wheal size >9.7 mm and a sIgE >0.42 kUA/L, with 100%/95.7% sensitivity and 75.0%/83.3% specificity, respectively. Co-sensitisation between Lep d and Der p was high, 75.0%. Asthma was more frequent in the positive Lep d NPT group (54 vs. 12%, p < 0.05). Significantly more patients from this group reported physical exercise, nonspecific irritants, and respiratory infections as relevant triggers of respiratory symptoms (p < 0.01–p < 0.05). Conclusions: To our knowledge, this is the first study to show that sensitisation to Lep d may have clinical relevance in a non-occupational setting. In this group, there seems to be a relationship between allergy to Lep d and severity of respiratory disease, with more bronchial inflammation, when comparing with mite-allergic patients sensitised only to HDM. Therefore, the authors consider that sensitisation to Lep d should be considered when assessing and treating allergic respiratory disease in urban environments.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Relevance of Lepidoglyphus destructor Sensitisation in Allergic Rhinitis: Nasal Provocation Test as in vivo Assessment

Matos Semedo,

Martins,

Tomaz

et al. 2024

Int Arch Allergy Immunol

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“…Also, molecular allergens can be missing (unknown or commercially unavailable) for many rare allergens, for example, storage mites or shrimp. 10 , 11 This, after many years, keeps the door wide open for the standard allergy diagnostic pathway based on extracts from natural sources for skin tests but also in vitro tests. Extracts from natural sources offer the advantage of including a lot of minor allergen components and variants of the major allergens that are sometimes missing even in very well‐known allergens; for example, the major birch pollen allergen Bet v1 is currently listed in 28 isoforms on the IUIS Allfam Server.…”

Section: Discussionmentioning

confidence: 99%

“…If screening includes only the most prevalent variants of major allergens, allergic patients with sensitizations to minor allergens will produce false negative tests. Also, molecular allergens can be missing (unknown or commercially unavailable) for many rare allergens, for example, storage mites or shrimp 10,11 . This, after many years, keeps the door wide open for the standard allergy diagnostic pathway based on extracts from natural sources for skin tests but also in vitro tests.…”

Section: Discussionmentioning

confidence: 99%

Allergy screening with extract‐based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing

Gureczny

Heindl

Klug

et al. 2023

Clinical & Translational All

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Background As extract‐based skin testing as well as in vitro tests for major allergens have their own advantages, both procedures are usually performed in routine settings. In times of shortages in medical staff and supplies, we asked ourselves, how many patients would be underdiagnosed, if only one test could be used. Methods In a retrospective analysis, we investigated a cohort of 2646 patients seen by a single physician in a large Austrian outpatient allergy clinic in 2018. Only patients with an allergen source‐specific history and pairs of extract‐based skin prick (SPT) and in vitro molecular allergy tests to major allergens were included. Results For all tested allergen sources, sensitivity was higher for SPT than for sIgE‐based molecular allergy testing. Concerning 1006 birch pollen‐allergic patients, 791 (78.6%) had positive results with both tests, while 153 (15.2%) only with the SPT and 62 (6.2%) only with the sIgE to Bet v1. The other allergen sources showed similar results: For house dust mite 816/1120 (72.9%), grass pollen 1077/1416 (76.1%) and cat 433/622 (69.6%) remained test‐positive with both procedures, whereas in 276 (24.6%), 224 (15.8%) and 173 (27.8%) times only the SPT and 28 (2.5%), 115 (8.1%) and 16 (2.6%) times only the sIgE to Der p1/2/23, Phl p1/5 and Fel d1 showed a positive result. Each comparison was statistically significant (each p < 0.0001, Chi‐squared test). Conclusions Screening for allergy with major molecular allergens has lower sensitivity when compared with extract‐based skin tests. A combination of both is required for an optimal sensitivity.

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Identification of rBlo t 41 with a chitin-binding type-2 domain: A novel major allergen from Blomia tropicalis

Luo,

Zhang,

Zheng

et al. 2024

International Journal of Biological Macromolecules

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Allergic sensitization to storage dust mites: a prospective study of patients with respiratory allergy

Cited by 5 publications

References 7 publications

Clinical Relevance of <i>Lepidoglyphus destructor</i> Sensitisation in Allergic Rhinitis: Nasal Provocation Test as in vivo Assessment

Clinical Relevance of <i>Lepidoglyphus destructor</i> Sensitisation in Allergic Rhinitis: Nasal Provocation Test as in vivo Assessment

Allergy screening with extract‐based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing

Identification of rBlo t 41 with a chitin-binding type-2 domain: A novel major allergen from Blomia tropicalis

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